Simultaneous enantioseparation of methcathinone and two isomeric methylmethcathinones using capillary electrophoresis assisted by 2-hydroxyethyl-β-cyclodextrin

Electrophoresis
Paweł NowakPaweł Kościelniak

Abstract

Methcathinone (ephedrone), 4-methylmethcathinone (mephedrone), and 3-methylmethcathinone (metaphedrone) are toxicologically-important cathinone derivatives used commonly as designer drugs. In this work we show the first method allowing to separate simultaneously all these molecules in a chiral medium, ensuring good resolution between all enantiomers. Eight cyclodextrins have been tested as potential chiral selectors, the best results were obtained with 2-hydroxyethyl-β-cyclodextrin, unreported so far for efficient separation of cathinones. After optimization, the method was calibrated and validated with and without the use of internal standard. The addition of standard improved an overall repeatability and precision, the use of electrophoretic mobility ratio was especially favorable (RSD < 1%). It was demonstrated that the method may be easily extended by introducing the additional cathinone-related drugs to the sample, maintaining satisfactory separation efficiency.

References

Oct 5, 2014·Forensic Science International : Synergy·Magdalena TaschwerMartin G Schmid
Jul 30, 2016·Rapid Communications in Mass Spectrometry : RCM·Christopher M Rollman, Mehdi Moini
Mar 7, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Alexandra MaasCornelius Hess

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Citations

Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raymond B Yu, Joselito P Quirino
Apr 28, 2020·Journal of Separation Science·Albert Pérez-AlcarazCarme Aguilar
Jun 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pavel ŘezankaMartin Kuchař
May 17, 2019·Electrophoresis·Albert Pérez-AlcarazMarta Calull
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Jul 16, 2019·Analytical Chemistry·Paweł M Nowak, Paweł Kościelniak
Jun 21, 2021·Electrophoresis·Chiara FanaliSalvatore Fanali

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