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Simultaneous estimation of transcript abundances and transcript specific fragment distributions of RNA-Seq data with the Mix2 model

bioRxiv

Jun 4, 2014

Andreas Tuerk, Gregor Wiktorin

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Abstract

Quantification of RNA transcripts with RNA-Seq is inaccurate due to positional fragmentation bias, which is not represented appropriately by current statistical models of RNA-Seq data. Another, less investigated, source of error is the inaccuracy of transcript start and end annotations....read more

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probe gene fragment
RNA
Research Study
Genes
Transcript
Abnormal Fragmented Structure
4
15
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Simultaneous estimation of transcript abundances and transcript specific fragment distributions of RNA-Seq data with the Mix2 model

bioRxiv

Jun 4, 2014

Andreas Tuerk, Gregor Wiktorin

DOI: 10.1101/005918

Abstract

Quantification of RNA transcripts with RNA-Seq is inaccurate due to positional fragmentation bias, which is not represented appropriately by current statistical models of RNA-Seq data. Another, less investigated, source of error is the inaccuracy of transcript start and end annotations....read more

Mentioned in this Paper

probe gene fragment
RNA
Research Study
Genes
Transcript
4
15

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