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Simultaneous estimation of transcript abundances and transcript specific fragment distributions of RNA-Seq data with the Mix2 model

bioRxiv

Jun 4, 2014

Andreas Tuerk, Gregor Wiktorin

Abstract

Quantification of RNA transcripts with RNA-Seq is inaccurate due to positional fragmentation bias, which is not represented appropriately by current statistical models of RNA-Seq data. Another, less investigated, source of error is the inaccuracy of transcript start and end annotations....read more

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Abnormal Fragmented Structure
Genes
probe gene fragment
Transcript
RNA
Research Study
4
15
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Simultaneous estimation of transcript abundances and transcript specific fragment distributions of RNA-Seq data with the Mix2 model

bioRxiv

Jun 4, 2014

Andreas Tuerk, Gregor Wiktorin

PMID: 990005918

DOI: 10.1101/005918

Abstract

Quantification of RNA transcripts with RNA-Seq is inaccurate due to positional fragmentation bias, which is not represented appropriately by current statistical models of RNA-Seq data. Another, less investigated, source of error is the inaccuracy of transcript start and end annotations....read more

Mentioned in this Paper

Abnormal Fragmented Structure
Genes
probe gene fragment
Transcript
RNA
Research Study
4
15

Similar Papers Found In These Feeds

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

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