PMID: 6166717May 1, 1981Paper

Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virus-specific cytotoxic T lymphocytes

The Journal of Experimental Medicine
T J BracialeV L Braciale

Abstract

Based on theoretical considerations and several types of experimental evidence with heterogeneous cell populations it has been proposed that alloreactive T cells and major histocompatibility complex (MHC)-restricted T cells directed to foreign non-NHC antigens represent overlapping subsets. In this report we provide direct evidence for this hypothesis at the clonal level. We have isolated a cloned continuous influenza virus-specific cytotoxic T cell (CTL) line derived from a single (H-2b X H-2d)F1 CTL precursor which simultaneously exhibits H-2-restricted cytotoxicity of influenza A/Japan/305/57 virus in association with H-2Kd and alloreactive cytotoxicity for H-2Kk alloantigen. Cold target inhibition data demonstrate that both MHC-restricted and alloreactive recognition is mediated by the same cell population. In addition to cross-reactivity at the target cell level, we shown that this cloned CTL line can be specifically stimulated to proliferate either by A/Japan/305/57 virus-infected cells expressing H-2Kd or by uninfected cells of the H-2Kk haplotype.

References

Aug 1, 1979·European Journal of Immunology·H von BoehmerW Haas
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M J Bevan
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America
Apr 1, 1981·The Journal of Experimental Medicine·T J BracialeV L Braciale
Oct 30, 1980·Nature·B Sredni, R H Schwartz

❮ Previous
Next ❯

Citations

Jan 1, 1983·Immunogenetics·V H Engelhard, C Benjamin
Jul 30, 1982·Journal of Immunological Methods·W Haas, H Von Boehmer
Jun 1, 1994·Current Opinion in Immunology·S R Webb, N R Gascoigne
Aug 1, 1994·Current Opinion in Immunology·L K Selin, R M Welsh
Feb 21, 2004·Journal of Neuroimmunology·Antonella FacchinettiGiovanni Biasi
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C L Kuo, L Hood
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E S SongR S Goodenow
Sep 1, 1987·The Journal of Experimental Medicine·D KoellerJ Forman
Jun 19, 2003·The Journal of Clinical Investigation·Andrew B AdamsChristian P Larsen
Jan 1, 1996·International Reviews of Immunology·O J FinnD K Bishop
Nov 19, 2003·The Journal of Cell Biology·Dmitry E ShvartsmanYoav I Henis
Oct 3, 2013·Expert Opinion on Biological Therapy·Leonardo V Riella, Mohamed H Sayegh
Aug 1, 2011·Kidney International Supplements·Leonardo V Riella, Mohamed H Sayegh
Jul 11, 2006·Immunological Reviews·Liisa K SelinRaymond M Welsh
Mar 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G EineckeP F Halloran
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A Fishman
Jan 11, 2012·Scandinavian Journal of Immunology·Z A Nagy
Jul 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A BrehmR M Welsh
Apr 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A ValujskikhR L Fairchild
Nov 6, 2004·Seminars in Immunology·Liisa K SelinRaymond M Welsh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.