Simultaneous expression of the ras p21 and p53 proteins in human endometrial carcinomas

Acta histochemica
R MiturskiJ Jakowicki

Abstract

The expression of ras-encoded p21 and p53 proteins was analyzed by immunohistochemical staining with monoclonal antibodies in 26 paraffin-embedded specimens (25 endometrial carcinomas and 1 uterine carcinosarcoma) taken from Polish women. The biotin-streptavidin-peroxidase detection system was employed. ras p21 protein was expressed in 68% of the specimens and p53 positive staining was noted in 36% of the carcinomas. Simultaneous expression of the ras p21 and p53 proteins was demonstrated in 8 (32%) out of the 25 specimens. Except one case, where the p53 protein was expressed, ras p21 protein was also detected. Both proteins were demonstrated in the sole case of carcinosarcoma. A difference between the detection of simultaneous expression of the ras p21 and p53 proteins in correlation with FIGO stages I to II-IV has been reported (22% v. 57% respectively). These data indicate, that ras p21 correlated with p53 positive staining in one-third of the endometrial cancers analyzed. The simultaneous detection of both proteins correlated with the advanced clinical stage of human endometrial carcinomas.

References

Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Dec 16, 1993·Nature·M S Boguski, F McCormick
Feb 1, 1994·The American Journal of Pathology·Z H LiD Shibata

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Citations

Jun 11, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R MiturskiJ A Jakowicki
Aug 23, 2002·Experimental Biology and Medicine·Roman MiturskiDominique Burnouf

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