Simultaneous eyelid and choroidal metastases 36 years after diagnosis of medullary thyroid carcinoma

Ophthalmic Plastic and Reconstructive Surgery
Carlos G BianciottoJ A Shields

Abstract

A 56-year-old man had a 6-month history of a progressively enlarging mass of his right upper eyelid. Thirty-six years previously he had undergone thyroidectomy for medullary thyroid carcinoma in the absence of family history. Supraclavicular lymph node metastases were discovered 3 years after initial diagnosis, pulmonary metastasis 26 years later, and cervical lymph node metastases 35 years later. Ocular examination revealed a pedunculated, amelanotic, highly vascularized metastasis involving the right upper eyelid and palpebral conjunctiva. Ophthalmoscopy revealed 2 amelanotic, dome-shaped choroidal metastases in the right eye and 3 similar tumors in the left eye. Medullary thyroid carcinoma not associated with the multiple endocrine neoplasia syndromes can metastasize to the ocular region and metastases can occur decades after the original diagnosis.

References

Aug 1, 1997·Ophthalmology·C L ShieldsS E Lally
Oct 18, 2002·American Journal of Ophthalmology·Jerry A ShieldsNoel Perez
Sep 10, 2004·Clinical Endocrinology·Sophie LeboulleuxMartin Schlumberger
Jan 13, 2006·Thyroid : Official Journal of the American Thyroid Association·F RosárioL G Sobrinho
Jan 16, 2007·Retina·Stephen E Palm, Dion Paridaens

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Citations

Oct 23, 2012·Thyroid : Official Journal of the American Thyroid Association·Nikola Besic, Zala Luznik
Apr 8, 2011·Journal français d'ophtalmologie·B GuignierO Schneegans
Sep 23, 2008·Ophthalmic Plastic and Reconstructive Surgery·Katherine MasselosIan C Francis
Dec 16, 2020·American Journal of Ophthalmology Case Reports·Sneh S DhannawatRosanna Bahadur

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