Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

Angewandte Chemie
Li-Sen LinXiaoyuan Chen

Abstract

Chemodynamic therapy (CDT) utilizes iron-initiated Fenton chemistry to destroy tumor cells by converting endogenous H2 O2 into the highly toxic hydroxyl radical (. OH). There is a paucity of Fenton-like metal-based CDT agents. Intracellular glutathione (GSH) with . OH scavenging ability greatly reduces CDT efficacy. A self-reinforcing CDT nanoagent based on MnO2 is reported that has both Fenton-like Mn2+ delivery and GSH depletion properties. In the presence of HCO3- , which is abundant in the physiological medium, Mn2+ exerts Fenton-like activity to generate . OH from H2 O2 . Upon uptake of MnO2 -coated mesoporous silica nanoparticles (MS@MnO2 NPs) by cancer cells, the MnO2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn2+ , resulting in GSH depletion-enhanced CDT. This, together with the GSH-activated MRI contrast effect and dissociation of MnO2 , allows MS@MnO2 NPs to achieve MRI-monitored chemo-chemodynamic combination therapy.

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Citations

Nov 1, 2018·Organic & Biomolecular Chemistry·Zhitao LeiZhigang Xie
Jul 23, 2019·Advanced Materials·Bowen YangJianlin Shi
Aug 28, 2019·Nanoscale·Ziliang DongLiangzhu Feng
Feb 6, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Weiqi WangHaijun Yu
Jan 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liang YanMin Wei
Jun 5, 2020·Chemical Communications : Chem Comm·Jia WenShiguo Sun
Jul 3, 2020·Chemical Communications : Chem Comm·Li WangAhu Yuan
Aug 19, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lile DongGuobin Hong
Apr 3, 2019·The Journal of Gene Medicine·Jiayan WuXuesi Chen
Aug 30, 2019·Chemical Society Reviews·Lijiao YangXiaoyuan Chen
Jun 15, 2019·Journal of Nanobiotechnology·Bin ZhaoQianjun He
Nov 21, 2019·Angewandte Chemie·Kanyi Pu, Hai-Yan Xie
May 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuiling JinWei Jiang
Apr 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Baofeng YunZhen Li
Jul 24, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Shuhua CaoXishi Tai

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