Simultaneous hepatectomy and splenectomy versus hepatectomy alone for hepatocellular carcinoma complicated by hypersplenism: a meta-analysis

OncoTargets and Therapy
Wei LiRui-Chen Yan

Abstract

This study systematically compared the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy (H) alone in patients with hepatocellular carcinoma (HCC) and hypersplenism. The PubMed, Web of Science, Science Direct, EMBASE, and Cochrane Library databases were systematically searched by two independent researchers through to March 31, 2015 to identify relevant studies. All the extracted literature were managed by Bibliographic citation management software. Quality assessment of the included studies was performed using a modified Newcastle-Ottawa Scale judgment. The data were analyzed using RevMan5.2 software. Eight studies including a total of 761 patients with HCC and hypersplenism (360 in the HS group, 401 in the H group) were finally included in the analysis. Outcomes, including postoperative complications, perioperative mortality, operation time, 5-year survival rate, and need for blood transfusion did not differ significantly between the two groups. HS was associated with significantly more intraoperative bleeding (mean difference [MD] 57.15, 95% confidence interval [CI] 18.83-95.46, P=0.003), and CD4/CD8 ratio (MD 0.69, 95% CI 0.61-0.77, P<0.00001), CD4 subset, platelet count (MD 213.06, 95% C...Continue Reading

Citations

Mar 28, 2017·The Journal of Surgical Research·Benjamin DarnisJean-Yves Mabrut
May 12, 2017·British Journal of Haematology·Joji ShimonoKoichi Ohshima
Oct 23, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Youliang PeiWanguang Zhang
Oct 18, 2019·Cancers·Quirino LaiUNKNOWN Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group
Dec 5, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Youliang PeiWanguang Zhang

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