Simultaneous high-performance liquid chromatographic determination of residual sulphamonomethoxine, sulphadimethoxine and their N4-acetyl metabolites in foods of animal origin

Journal of Chromatography. a
N Furusawa, T Mukai

Abstract

A rapid and sensitive method for the determination of residual sulphamonomethoxine, sulphadimethoxine and their N4-acetyl metabolites in beef, pork, chicken and eggs by high-performance liquid chromatography (HPLC) was developed. The extraction of these compounds was performed using a mixture of 90% (v/v) acetonitrile solution and hexane (5:4, v/v) to minimize the fat content followed by purification by alumina column chromatography. These extracts contained sulphonamide analytes which were free from interfering compounds when examined by HPLC using a LiChrosorb RP-18 column. The average recoveries from spiked meat and egg were in excess of 80% with relative standard deviations between 0.4 and 5.0%. The practical limits of detection were 0.01 ppm for all samples.

Citations

Mar 15, 2006·Analytical and Bioanalytical Chemistry·M Gratacós-CubarsíJ A García-Regueiro
Jan 30, 1999·British Poultry Science·N Furusawa, Y Tsuzukida
Jul 3, 1998·British Poultry Science·N FurusawaH Yamaguchi
Aug 11, 1998·Zentralblatt für Veterinärmedizin. Reihe A·N FurusawaH Yamaguchi
Aug 28, 1998·Zentralblatt für Veterinärmedizin. Reihe A·N Furusawa
May 11, 2005·Journal of Separation Science·Juan José Berzas NevadoFrancisco Javier Guzmán Bernardo
Feb 17, 2009·Journal of Separation Science·Rodrigo Hoff, Tarso B L Kist

Related Concepts

N(4)-acetylsulfadimethoxine
N(4)-acetylsulfamonomethoxine
Metazoa
Bos indicus
High Pressure Liquid Chromatography Procedure
Drug Residues
Egg Food Product
Food Analysis
Hydrogen-Ion Concentration
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