Simultaneous Identification of Multiple β-Lactamases in Acinetobacter baumannii in Relation to Carbapenem and Ceftazidime Resistance, Using Liquid Chromatography-Tandem Mass Spectrometry

Journal of Clinical Microbiology
Hein TripArmand Paauw

Abstract

Shotgun proteomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was applied to detect β-lactamases in clinical Acinetobacter baumannii isolates. The correlation of the detection of β-lactamase proteins (rather than PCR detection of the corresponding genes) with the resistance phenotypes demonstrated an added value for LC-MS/MS in antimicrobial susceptibility testing.

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Citations

Apr 12, 2016·Frontiers in Microbiology·Francisco J Pérez-Llarena, Germán Bou
Aug 11, 2016·Frontiers in Microbiology·Claude Saint-RufIvan Matic
Dec 21, 2017·Molecular & Cellular Proteomics : MCP·Tiphaine CecchiniJean-Philippe Charrier
May 22, 2020·Clinical Proteomics·Fumio NomuraKazuyuki Matsushita
Apr 12, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F FleurbaaijE J Kuijper
Sep 27, 2019·Frontiers in Microbiology·Karim HayounBéatrice Alpha-Bazin
Dec 1, 2019·International Journal of Medical Microbiology : IJMM·Erwin M BerendsenArmand Paauw
Oct 27, 2021·Analytical Chemistry·Christian BlumenscheitJoerg Doellinger

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