Abstract
Adverse drug reactions of Danshen injection mainly manifested as pseudoallergic reactions. In the present study, salvianolic acid A and a pair of geometric isomers (isosalvianolic acid C and salvianolic acid C) were identified as pseudoallergic components in Danshen injection by a high-expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled online with high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Their pseudoallergic activities were evaluated by in vitro assay, which were consistent with the retention times on the cell membrane chromatography column. Salvianolic acid C, the most outstanding compound, was further found to induce pseudoallergic reaction through Mas-related G protein coupled receptor X2. All the results above indicated that the system developed in this study is an effective method for simultaneously analyzing pseudoallergic components, even those with similar structures and the microcomponents in complex samples (salvianolic acid C in Danshen injection).
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Citations
Jun 2, 2020·Biological & Pharmaceutical Bulletin·Yuanyuan ZhangLi Chu
Apr 14, 2020·Journal of Separation Science·Yuanyuan LinShengli Han
Jan 26, 2021·Journal of Separation Science·Wei SunShengli Han
Jan 29, 2021·Analytical and Bioanalytical Chemistry·Liyang ZhangShengli Han