Simultaneous inhibition of NMDA and mGlu1/5 receptors by levo-corydalmine in rat spinal cord attenuates bone cancer pain

International Journal of Cancer. Journal International Du Cancer
Wenling DaiBo-Yang Yu

Abstract

Bone cancer pain is a challenge for its not completely clarified mechanism and broad clinical morbidity. Therefore, novel and more effective drugs are urgent needed for improvement of patients' quality of life. Glutamate receptors have been associated with the development of the central sensitization of chronic pain. Inhibition of N-methyl-d-aspartate (NMDA) and metabotropic glutamate (mGlu) receptors can effectively attenuate bone cancer pain, respectively. Herein, our results indicated that levo-Corydalmine (l-CDL), a compound from Corydalis yanhusuo W.T. Wang, which has been used in traditional Chinese medicine for pain relief could effectively attenuate bone cancer pain induced by tibia bone cavity tumor cell implantation (TCI) through simultaneously inhibiting the NMDA and mGlu1/5 receptors in rat spinal cord without notable side effects. Both intragastric and intrathecal administration of l-CDL significantly alleviated the mechanical hypersensitivity induced by TCI in rats, and the analgesic effect of l-CDL could be reversed by intrathecal administration of NMDA receptor agonist NMDA and mGlu1/5 receptor agonist DHPG but not AMPA receptor agonist AMPA. l-CDL could also selectively suppress NMDA and DHPG induced rapid rise...Continue Reading

References

Jul 1, 1992·Trends in Pharmacological Sciences·B Sommer, P H Seeburg
Sep 15, 2001·Nature·D Julius, A I Basbaum
May 7, 2002·Nature Reviews. Cancer·Patrick W MantyhSteve P Hunt
Mar 23, 2004·Nature Reviews. Neuroscience·Michael W Salter, Lorraine V Kalia
Oct 12, 2005·Life Sciences·Christopher R McCurdy, Stephen S Scully
Apr 1, 2006·Pharmacology & Therapeutics·Gurpreet K Dhami, Stephen S G Ferguson
May 27, 2006·Biochemical and Biophysical Research Communications·Qi-Liang Mao-YingYan-Qing Wang
Jun 13, 2006·Pharmacology, Biochemistry, and Behavior·Sayoko Suetake-KogaToshio Honda
Sep 9, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Osamu SaitoTatsuo Yamamoto
Nov 18, 2006·Seminars in Cell & Developmental Biology·David BleakmanEric S Nisenbaum
Mar 16, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M H J van den Beuken-van EverdingenJ Patijn
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Aug 22, 2007·Cellular and Molecular Neurobiology·Hongyuan ChuXuechu Zhen
Aug 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Alban Latremoliere, Clifford J Woolf
Mar 23, 2011·Molecular Pharmacology·Lakshmi KelamangalathThomas F Murray
Apr 8, 2011·Frontiers in Neuroscience·L Ashley BlackshawRichard L Young
Jun 28, 2011·Lancet·Russell K Portenoy
Nov 2, 2011·Current Opinion in Pharmacology·Santina Chiechio, Ferdinando Nicoletti
May 26, 2012·Nature Neuroscience·Jelena Radulovic, Natalie C Tronson
Aug 7, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Amy Lee BredlauRobert H Dworkin
May 17, 2014·Trends in Neurosciences·Ceng LuoRohini Kuner
Jun 21, 2014·Nature Reviews. Drug Discovery·Ru-Rong JiYong-Jing Gao
Jun 25, 2014·The Journal of Pharmacology and Experimental Therapeutics·Zhengyu CaoThomas F Murray
Oct 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiao-Dong HuXian Yang
Jun 15, 2016·Current Neuropharmacology·Kohei KogaMin Zhuo

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Citations

Oct 17, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lin ZhouYunman Li
Jul 5, 2019·Cellular and Molecular Neurobiology·Chengwei YangJuan Li
Oct 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia SunDa-Wei Ye

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