Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II--clinical results

International Journal of Radiation Oncology, Biology, Physics
Andrew LauveEvan Reiter

Abstract

To perform a Phase I radiation dose-escalation trial to determine the maximal tolerable dose (MTD) deliverable to the gross tumor volume (GTV) using an accelerated fractionation with simultaneous integrated boost intensity-modulated radiotherapy regimen with parotid gland sparing as the sole therapy in the treatment of locally advanced head-and-neck squamous cell carcinoma. The primary objective was the definition of the MTD using established criteria of quantifying acute dose-limiting toxicity (DLT). Secondary objectives included analysis of failure patterns, tumor control rates, and toxicity. Between July 1999 and June 2002, eligible patients with bulky Stage II to Stage IVB head-and-neck squamous cell carcinoma, excluding laryngeal primaries, were enrolled. Intensity-modulated radiotherapy was delivered with 6-MV photons using a "sliding-window" technique. Enrollment of 6 patients for each dose level was planned; if DLTs were seen in >2 of 6 patients, the previous dose was to be expanded by an additional 6 patients to confirm that dose level as the MTD. All schedules administered a total of 30 fractions, but with escalating doses per fraction (2.27, 2.36, and 2.46 Gy) to achieve a total dose to the GTV of 68.1, 70.8, and 73....Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·K K AngB W Brown
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
Apr 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J G MiraI L Shannon
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J S CooperS Silverman
Jan 1, 1993·International Journal of Radiation Oncology, Biology, Physics·I H ValdezP C Fox
Aug 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B MaciejewskiR Suwinski
Apr 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M JacksonJ S Durham
Sep 7, 1999·International Journal of Radiation Oncology, Biology, Physics·P J NowakP C Levendag
Mar 4, 2000·International Journal of Radiation Oncology, Biology, Physics·R MohanR Schmidt-Ullrich
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·L A DawsonA Eisbruch
Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·V GrégoireH Reychler
Aug 16, 2000·Physics in Medicine and Biology·Q WuR Mohan
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·M A HuntS A Leibel
Dec 4, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Dörr, J H Hendry
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Monica M MorrisCyrus Amir
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Rafal TarnawskiAndrzej Wygoda
Jan 16, 2003·International Journal of Radiation Oncology, Biology, Physics·K S Clifford ChaoDaniel A Low

❮ Previous
Next ❯

Citations

Mar 3, 2010·International Journal of Clinical Oncology·Pierre HeudelPascal Pommier
Jul 17, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O BallivyF Guedea Edo
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Antonio Vila CapelGemma Carrera Domenech
Aug 24, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P Giraud, S Servagi-Vernat
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·X Allen LiDian Wang
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Jeffrey V SiebersRupert K Schmidt-Ullrich
Jan 18, 2006·International Journal of Radiation Oncology, Biology, Physics·Chikao SugieTakuya Hashizume
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Suzanne L WoldenMichael J Zelefsky
Nov 3, 2005·Nature Clinical Practice. Oncology·Avraham Eisbruch
Apr 9, 2005·Current Opinion in Oncology·William P O'Meara, Nancy Lee
Apr 9, 2005·Current Opinion in Oncology·Theodore S HongPaul M Harari
Jul 14, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Samir Narayan
Oct 16, 2013·Oral Oncology·Michael K M KamAnne W M Lee
Aug 31, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·G Brandon GunnGiuseppe Sanguineti
Mar 9, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S K HuiS Levitt
Dec 3, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Michele AvanzoElvira Capra
Feb 8, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Carmen StrombergerSimone Marnitz
Dec 18, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Savino CillaAlessio G Morganti
Jul 17, 2012·Otolaryngologic Clinics of North America·Harry Quon, Jeremy D Richmon
Aug 9, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·S CillaA G Morganti
Dec 21, 2010·International Journal of Radiation Oncology, Biology, Physics·Michael E MontejoYing J Hitchcock
Dec 15, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Emmy Lamers-KuijperCoen Rasch
Sep 22, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wonsik ChoiSeung Do Ahn
Jul 8, 2010·International Journal of Radiation Oncology, Biology, Physics·Richard L BakstSuzanne L Wolden
Mar 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Madelon Pijls-JohannesmaPhilippe Lambin
Oct 27, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A HuchetH Loiseau
Jul 7, 2009·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Ramachandran PrabhakarGoura K Rath
Dec 23, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicolas ChristianVincent Grégoire
Nov 26, 2008·Seminars in Radiation Oncology·Avraham Eisbruch, Vincent Gregoire
Jun 17, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniel E SotoAvraham Eisbruch
Apr 26, 2008·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Peter NiehoffJörg Wiltfang
Oct 31, 2007·International Journal of Radiation Oncology, Biology, Physics·C Wesley HodgePaul M Harari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.