Abstract
We analyzed outcomes of simultaneous integrated boost (SIB) intensity-modulated radiotherapy (IMRT) in patients with high-grade gliomas, compared with a literature review. Forty consecutive patients (WHO grade III, 14 patients; grade IV, 26 patients) treated with SIB-IMRT were analyzed. A dose of 2.0 Gy was delivered to the planning target volume with a SIB of 0.4 Gy to the gross tumor volume with a total dose of 60 Gy to the gross tumor volume and 50 Gy to the planning target volume in 25 fractions during 5 weeks. Twenty patients received temozolomide chemotherapy. At a median follow-up of 13.4 months (range, 3.7-55.9 months), median survival was 14.8 months. One- and 2-year survival rates were 78% and 65%, respectively, for patients with grade III tumors and 56% and 31%, respectively, for patients with grade IV tumors. Age (≤50 vs. >50), grade (III vs. IV), subtype (astrocytoma vs. oligodendroglioma or mixed), and a Zubrod performance score (0-1 vs. >2) were predictive of survival. Of 25 (63%) patients who had recurrences, 17 patients had local failure, 9 patients had regional failure, and 1 patient had distant metastasis. Toxicities were acceptable. SIB-IMRT with the dose/fractionation used in this study is feasible and safe...Continue Reading
References
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·K E WallnerM G Malkin
Oct 1, 1988·Journal of Neurosurgery·L G SalfordS Nirfalk
May 5, 1993·Journal of the National Cancer Institute·W J CurranR E Krisch
Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·M D PradosD A Larson
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·C ThilmannJ Debus
Aug 17, 2002·Neurosurgery·Robert G SelkerUNKNOWN Brain Tumor Cooperative Group
Dec 20, 2003·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Maria F ChanC Clifton Ling
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Khalil SultanemLuis Souhami
Jul 9, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Carsten NiederMichael Molls
Oct 7, 2004·International Journal of Radiation Oncology, Biology, Physics·Luis SouhamiWalter J Curran
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Toshihiko IuchiKatsunobu Osato
Jan 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Ulrich HermantoShiao Y Woo
Sep 4, 2007·Head & Neck·Woong Sub KoomKwan Ho Cho
Mar 1, 2008·International Journal of Clinical Oncology·Kiyoshi NakamatsuFumiharu Akai
Jun 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Valerie Panet-RaymondGeorge Shenouda
Jan 2, 2009·International Journal of Radiation Oncology, Biology, Physics·Kwan Ho ChoJin Soo Lee
Feb 13, 2010·Cancer·Ute Linz
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Nicholas S BoehlingShiao Y Woo
Citations
Feb 7, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Kenji HirataNagara Tamaki
Aug 16, 2012·International Journal of Clinical Oncology·Mariangela MassaccesiAlessio G Morganti
Nov 26, 2013·Annals of Nuclear Medicine·Reinhart SweeneyFrederik A Verburg
Mar 3, 2012·Medical Physics·Ady AbdellatifEugene Wong
Jul 3, 2015·Oncology Letters·Takuma NomiyaKenji Nemoto
Dec 18, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Savino CillaAlessio G Morganti
Dec 12, 2012·Microvascular Research·Preety SharmaPeter Grabham
Jul 17, 2012·Hematology/oncology Clinics of North America·Toral R PatelJoseph M Piepmeier
Jan 27, 2016·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Supriya MallickGoura Kishor Rath
Jun 1, 2013·Journal of Medical Imaging and Radiation Oncology·James C MarshJulius V Turian
Dec 14, 2011·Brain Research·William FauquetteMichel Diserbo
Sep 6, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mostafa FarzinMarkus Oechsner
Mar 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Young Suk KimChang-Ok Suh
Sep 3, 2013·Brain Research·Masahiro OnoYoshifumi Shirakami
Aug 16, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L FeuvretJ-J Mazeron
Dec 3, 2016·Radiation Research·Thomas TemplinPeter Grabham
Dec 21, 2011·Technology in Cancer Research & Treatment·K H ChoH C Park
Nov 14, 2014·PloS One·Nikolett SándorHargita Hegyesi
Jan 7, 2015·World Journal of Gastroenterology : WJG·Takuma NomiyaKenji Nemoto
Apr 6, 2019·Indian Journal of Cancer·Ozan Cem GulerErkan Topkan
Sep 8, 2017·La Radiologia medica·Silvia ScocciantiLorenzo Livi
Dec 29, 2019·Radiation Oncology·Franziska EckertFrank Paulsen
Jun 15, 2019·Radiation Oncology·Liangzhi ZhongGuanghui Li
Apr 1, 2018·Journal of Neuro-oncology·Rory J PiperStephen J Price
Jun 25, 2018·Journal of Neuro-oncology·Supriya MallickGoura Kishor Rath
Jul 28, 2019·Journal of Clinical Medicine·Kenji HirataNagara Tamaki
Jul 8, 2020·Radiation Oncology·Han BaiJiawen Yan
Nov 20, 2016·Journal of Radiation Research·Katsuya YaharaYukunori Korogi
Sep 19, 2017·ANZ Journal of Surgery·Dasantha JayamanneMichael F Back
Oct 20, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Joana Spaggiari MarraHarley Francisco de Oliveira
Sep 14, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Mikaël AntoineJérôme Caron
Mar 27, 2021·Medical Physics·Erick Sebastian Rundo AcurioJuliana Fernandes Pavoni