Simultaneous integrated vs. sequential boost in VMAT radiotherapy of high-grade gliomas

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Mostafa FarzinMarkus Oechsner

Abstract

In 20 patients with high-grade gliomas, we compared two methods of planning for volumetric-modulated arc therapy (VMAT): simultaneous integrated boost (SIB) vs. sequential boost (SEB). The investigation focused on the analysis of dose distributions in the target volumes and the organs at risk (OARs). After contouring the target volumes [planning target volumes (PTVs) and boost volumes (BVs)] and OARs, SIB planning and SEB planning were performed. The SEB method consisted of two plans: in the first plan the PTV received 50 Gy in 25 fractions with a 2-Gy dose per fraction. In the second plan the BV received 10 Gy in 5 fractions with a dose per fraction of 2 Gy. The doses of both plans were summed up to show the total doses delivered. In the SIB method the PTV received 54 Gy in 30 fractions with a dose per fraction of 1.8 Gy, while the BV received 60 Gy in the same fraction number but with a dose per fraction of 2 Gy. All of the OARs showed higher doses (Dmax and Dmean) in the SEB method when compared with the SIB technique. The differences between the two methods were statistically significant in almost all of the OARs. Analysing the total doses of the target volumes we found dose distributions with similar homogeneities and comp...Continue Reading

References

Feb 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J E MarksW F Blank
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·C ThilmannJ Debus
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Anne W M LeeJohn F Fowler
Nov 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Nesrin DoganAnil Sethi
Jul 9, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Carsten NiederMichael Molls
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·X Allen LiDian Wang
Nov 9, 2005·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Shang-Wen ChenFang-Jen Lin
Mar 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Jeremy D RubenPasqual Fedele
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Toshihiko IuchiKatsunobu Osato
Jun 23, 2006·Physics in Medicine and Biology·Thomas Bortfeld
Aug 23, 2008·International Journal of Radiation Oncology, Biology, Physics·Abrahim Al-MamganiJoos V Lebesque
Jun 30, 2009·International Journal of Radiation Oncology, Biology, Physics·Richard ShafferKarl Otto
Jan 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Kwan Ho ChoHong Ryull Pyo
Dec 17, 2010·Physics in Medicine and Biology·Wensha YangKe Sheng
Jan 13, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Szu-Huai LuChun-Wei Wang
Mar 1, 2012·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Dante E RoaMuthana S A L Al-Ghazi
Apr 21, 2012·International Journal of Radiation Oncology, Biology, Physics·Vesna ProkicAnca-Ligia Grosu
May 21, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·N G BurnetS J Jefferies
Aug 26, 2014·Journal of Medical Imaging and Radiation Oncology·Chance MatthiesenSalahuddin Ahmad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Matthias GuckenbergerMichael Flentje
Journal of Applied Clinical Medical Physics
Caroline LafondJean-Pierre Manens
Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
Xiaofang DaiC-M Ma
© 2021 Meta ULC. All rights reserved