Simultaneous kidney and segmental pancreas transplants from living related donors - the first two successful cases

Transplantation
R W Gruessner, D E Sutherland

Abstract

Simultaneous pancreas and kidney transplants (SPKs) from cadaver donors have become a widely accepted treatment option for insulin-dependent (Type I diabetic) patients with end-stage nephropathy. However, for technically successful transplants, long-term success is better with living donors (LDs). Sequential kidney and pancreas transplants from LDs have been done, but until now SPKs from LDs have not been attempted. We report here 2 successful SPKs from LDs. Both recipients received a right kidney and distal pancreas: the first (a 28-year-old woman, diabetic since age 7) from her 54-year-old mother; the second (a 46-year-old man, diabetic since age 31) from his 44-year-old sister. Six months posttransplant both recipients have function of both grafts (serum creatinine < or = to 1.5 mg/dl; serum C-peptide normal range, fasting and stimulated). Thus, SPKs from LDs are technically feasible and could be an alternative to segmental transplants or cadaver SPKs for selected type I diabetic patients with end-stage nephropathy.

References

Jun 1, 1992·The Journal of Clinical Investigation·E R Seaquist, R P Robertson
Dec 1, 1984·Transplantation·D E SutherlandJ S Najarian

❮ Previous
Next ❯

Citations

Apr 9, 1998·Transplantation Proceedings·R W GruessnerD E Sutherland
Sep 2, 1998·Transplantation Proceedings·D E SutherlandR Gruessner
Feb 9, 2011·Diabetes Technology & Therapeutics·Cyrus JahansouzKenneth L Brayman
Nov 14, 1997·Annals of Surgery·R W GruessnerD E Sutherland
Aug 26, 1998·Annals of Surgery·H P GrewalJ M Millis
Apr 17, 2001·Annals of Surgery·D E SutherlandJ S Najarian
Aug 19, 2003·Transplantation·Adam ZielińskiEnrico Benedetti
Jan 22, 2011·Gut and Liver·Duck Jong Han, David Er Sutherland
Apr 27, 2010·Advances in Anatomic Pathology·Deepa T Patil, Lisa M Yerian
Jan 14, 2012·Current Opinion in Organ Transplantation·David E R SutherlandRaja Kandaswamy
Apr 29, 2014·Transplantation Proceedings·T KobayashiD E R Sutherland
Jul 14, 2004·Journal de chirurgie·J P Duffas
Nov 1, 2010·Insights Into Imaging·Frances A HampsonAshley S Shaw
Aug 5, 2009·Journal of Hepato-biliary-pancreatic Sciences·Jason F ReynosoRainer W G Gruessner
Jul 21, 2009·Journal of Hepato-biliary-pancreatic Sciences·Takehide Asano, Takashi Kenmochi
Jul 21, 2009·Journal of Hepato-biliary-pancreatic Sciences·Takashi KenmochiMariko Miyazaki
Apr 10, 2016·Journal of the Royal Society of Medicine·Shamik DholakiaVassilios Papalois
Jul 1, 2016·World Journal of Transplantation·Hany El-HennawyFowler Smith
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Miguel TanRainer W G Gruessner
Dec 8, 2004·Endocrine Reviews·Jennifer L Larsen
Oct 14, 2017·Transplantation Direct·Guosheng WuDaiming Fan
Jan 1, 2019·World Journal of Transplantation·Emmanouil GiorgakisAndrew L Singer
May 26, 2009·Lancet·Steve A WhiteDavid E R Sutherland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.