Simultaneous loss and reappearance of alpha 1-adrenergic responses and [3H]prazosin binding sites in rat liver after irreversible blockade by phenoxybenzamine
Biochimica Et Biophysica Acta
May 25, 1983
Christopher J LynchMichael L Steer
PMID: 6303440
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Abstract
The relative influences of the in vivo administration of phenoxybenzamine on in vitro binding to alpha 1-adrenergic receptors and alpha 1-receptor-mediated responses were studied. Phenoxybenzamine treatment reduced maximal specific binding of the alpha 1-selective antagonist [3H]prazosi...read more
Mentioned in this Paper
Phenylephrine Hydrochloride
Calcium
Pratsiol
Glucose, (beta-D)-Isomer
Norepinephrine Receptors
Phenoxybenzamine Hydrochloride
Alpha-adrenergic receptor
Quinazolines
Liver
Paper Details
References
- References9
- Citations3
Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine
Journal of Medicinal ChemistryJanuary 1, 1976J G HenkelP H Lewis
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
Biochemical PharmacologyDecember 1, 1973Yaofeng Cheng, William H Prusoff212153
Agonist versus antagonist binding to alpha-adrenergic receptors
Proceedings of the National Academy of Sciences of the United States of AmericaAugust 1, 1980Brenda B HoffmanJohn N Fain17
Blockade of hepatic alpha-adrenergic receptors and responses by chlorpromazine and trifluoperazine
FEBS LettersJanuary 26, 1981Peter F BlackmoreJohn H Exton
Hepatic alpha-adrenoreceptor: specific and irreversible labeling by [3H]-phenoxybenzamine
Biochemical and Biophysical Research CommunicationsAugust 28, 1979Georges Guellaën, Jacques HanouneAffinity labelling of alpha-adrenoceptors in intact liver cells by [3H]phenoxybenzamine
Biochemical and Biophysical Research CommunicationsNovember 14, 1979W H KanGeorge Kunos
On the evaluation of the constants Vm and KM in enzyme reactions
ScienceSeptember 26, 1952B H J HOFSTEEEffects of fasting on hepatic catecholamine receptors
FEBS LettersSeptember 20, 1982M F El-Refai, T M Chan
Cosmic radiation and cancer mortality
ExperientiaJuly 15, 1948Peter J Morris, W J Nickerson
1
- References9
- Citations3
Characterization of alpha-adrenoceptors in myometrium of preparturient rats
European Journal of PharmacologyOctober 29, 1985Jean-Paul Maltier, Chantal Legrand
Myelin basic protein is an endogenous inhibitor of the high-affinity cannabinoid binding site in brain
Journal of NeurochemistryApril 1, 1988J S NyeStephen Snyder111In vivo recovery of alpha 1-adrenoceptors in rat myocardial tissue after alkylation with phenoxybenzamine
European Journal of PharmacologyJanuary 1, 1994João Bosco SallesAlbert Badia
1
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Simultaneous loss and reappearance of alpha 1-adrenergic responses and [3H]prazosin binding sites in rat liver after irreversible blockade by phenoxybenzamine
Abstract
The relative influences of the in vivo administration of phenoxybenzamine on in vitro binding to alpha 1-adrenergic receptors and alpha 1-receptor-mediated responses were studied. Phenoxybenzamine treatment reduced maximal specific binding of the alpha 1-selective antagonist [3H]prazosi...read more
Mentioned in this Paper
Phenylephrine Hydrochloride
Calcium
Pratsiol
Glucose, (beta-D)-Isomer
Norepinephrine Receptors
Related Papers
Paper Details
References
- References9
- Citations3
Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine
Journal of Medicinal ChemistryJanuary 1, 1976J G HenkelP H LewisRelationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
Biochemical PharmacologyDecember 1, 1973Yaofeng Cheng, William H Prusoff212153Agonist versus antagonist binding to alpha-adrenergic receptors
Proceedings of the National Academy of Sciences of the United States of AmericaAugust 1, 1980Brenda B HoffmanJohn N Fain17Blockade of hepatic alpha-adrenergic receptors and responses by chlorpromazine and trifluoperazine
FEBS LettersJanuary 26, 1981Peter F BlackmoreJohn H ExtonHepatic alpha-adrenoreceptor: specific and irreversible labeling by [3H]-phenoxybenzamine
Biochemical and Biophysical Research CommunicationsAugust 28, 1979Georges Guellaën, Jacques HanouneAffinity labelling of alpha-adrenoceptors in intact liver cells by [3H]phenoxybenzamine
Biochemical and Biophysical Research CommunicationsNovember 14, 1979W H KanGeorge KunosOn the evaluation of the constants Vm and KM in enzyme reactions
ScienceSeptember 26, 1952B H J HOFSTEEEffects of fasting on hepatic catecholamine receptors
FEBS LettersSeptember 20, 1982M F El-Refai, T M ChanCosmic radiation and cancer mortality
ExperientiaJuly 15, 1948Peter J Morris, W J Nickerson
1
- References9
- Citations3
Characterization of alpha-adrenoceptors in myometrium of preparturient rats
European Journal of PharmacologyOctober 29, 1985Jean-Paul Maltier, Chantal LegrandMyelin basic protein is an endogenous inhibitor of the high-affinity cannabinoid binding site in brain
Journal of NeurochemistryApril 1, 1988J S NyeStephen Snyder111In vivo recovery of alpha 1-adrenoceptors in rat myocardial tissue after alkylation with phenoxybenzamine
European Journal of PharmacologyJanuary 1, 1994João Bosco SallesAlbert Badia
1
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