PMID: 2121073Oct 1, 1990Paper

Simultaneous measurement of all thrombosis parameters from native human blood: usefulness in monitoring efficacy and complications of thrombolytic therapy

Angiology
I B Kovacs, P Görög

Abstract

The sequelae of thrombus formation, both by shear forces and by collagen fiber, the subsequent coagulation, and the dislodgement of thrombi (thrombolysis) were measured from a small volume of nonanticoagulated blood sample, by a new instrument. Addition of streptokinase (SK) or tissue-type plasminogen activator (rt-PA) to the blood sample eliminated the need for anticoagulation for thrombolysis measurement: clot lysis preceded and allowed thrombolysis to occur. The test revealed activation of platelets and coagulation by SK and rt-PA. Apart from this general trend, platelet reactivity in response to plasminogen activator showed great individual variation. Whether the greatly enhanced (42%) or prolonged hemostasis (13%), observed in different blood samples with rt-PA, could be used as a predictor of reocclusion or bleeding complications remains to be established. Thrombolysis did not occur in 12% of the samples tested. These thrombolysis models may be useful for developing new agents for the dissolution of platelet-rich thrombi. It is suggested that this technique be used for monitoring thrombolytic therapy.

Citations

Feb 15, 1997·Thrombosis Research·H IkarugiJ Yamamoto
Mar 1, 1993·American Journal of Hematology·I B KovacsG M Rees
Sep 1, 1992·American Heart Journal·J E NaschitzJ Abrahamson
May 1, 1996·Academic Radiology·L G MeltonD A Gabriel
Feb 15, 1993·Cancer·J E NaschitzL M Lev
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·T IgawaJ Kambayashi

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