PMID: 8938622Oct 1, 1996Paper

Simultaneous measurement of metabolic flux in portally-drained viscera, liver, spleen, kidney and hindquarter in the conscious pig

Laboratory Animals
G A Ten HaveN E Deutz

Abstract

A method was developed to measure metabolic fluxes simultaneously across the portally-drained viscera (PDV), liver, spleen, kidney and hindquarter (HQ) in the conscious pig (20-25 kg). For this purpose, sampling catheters were implanted in the abdominal artery, portal vein, hepatic vein, splenic vein, renal vein and caval vein. Further, two extra infusion catheters were implanted in the splenic vein and abdominal artery. These allow continuous infusion of para-aminohippuric acid (PAH), providing a method for estimating the plasma flow of the liver, PDV, spleen, kidney and HQ. To minimize the postoperative recovery period of the pigs, great attention was paid to the housing conditions. After a recovery period of seven days, pigs were used for experiments twice a week. During the three weeks experimental period, food intake, body temperature, weight gain, blood gas data and plasma flow were monitored. Mean plasma flow was: liver 52 +/- 6, PDV 40 +/- 5, HQ 20 +/- 2, spleen 4 +/- 1 and kidneys 15 +/- 2 ml/kg body weight/min. These data were characteristic for a pig in a conscious normal resting and unstressed state. The long-term patency rate of the sampling catheters was very high (ranging from 75% to 100%). This was probably due ...Continue Reading

Citations

May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·P B SoetersN E Deutz
Dec 6, 2002·British Journal of Pharmacology·Maaike J BruinsNicolaas E P Deutz
Apr 22, 2011·The American Journal of Clinical Nutrition·Martijn PoezeNicolaas E P Deutz
Apr 11, 2015·Journal of the Science of Food and Agriculture·Lucrecia González-ValeroIgnacio Fernández-Fígares
Aug 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christopher RoseRajiv Jalan
Sep 16, 2008·Peptides·Pieter C van der PijlNicolaas E P Deutz
Oct 18, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gabriella A M Ten HaveNicolaas E P Deutz
Jun 23, 2015·PloS One·Gabriella A M Ten HaveNicolaas E P Deutz
May 5, 2016·Journal of the Science of Food and Agriculture·María Luz Rojas-CanoIgnacio Fernández-Fígares
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven W M Olde DaminkPeter B Soeters
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven W M Olde DaminkPeter B Soeters
Jun 17, 2008·Critical Care Medicine·Florian SimonHubert Schelzig
Feb 12, 2010·The American Journal of Clinical Nutrition·Martijn PoezeNicolaas E Deutz
Apr 13, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gabriëlla A M Ten HaveNicolaas E P Deutz
Jun 20, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lars M YtrebøNicolaas E P Deutz
Oct 25, 2006·Scandinavian Journal of Gastroenterology·Lars M YtrebøArthur Revhaug
Mar 17, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vikram SharmaNathan A Davies
May 4, 2013·Journal of Applied Physiology·Marion JourdanChristian Aussel
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·N E DeutzP B Soeters
Mar 11, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·J Wernerman
Dec 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M J BruinsN E P Deutz
Jun 4, 2015·American Journal of Physiology. Endocrinology and Metabolism·Marieke G SchoonemanMaarten R Soeters
Jun 17, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kelly E MercerBrian D Piccolo
Dec 24, 2002·Annals of Surgery·Maaike J BruinsNicolaas E P Deutz
Jan 15, 2002·American Journal of Physiology. Renal Physiology·Marcella M HallemeeschNicolaas E P Deutz
Feb 2, 2021·American Journal of Physiology. Endocrinology and Metabolism·Gabriella A M Ten HaveNicolaas E P Deutz
Oct 20, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·H M H van EijkN E P Deutz
Oct 5, 2021·American Journal of Physiology. Endocrinology and Metabolism·Sarah K KirschnerNicolaas E P Deutz

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