Simultaneous measurements of KL-6 and SP-D in patients undergoing thoracic radiotherapy.

Medical Oncology
Yosuke MatsunoKiyohisa Sekizawa

Abstract

Radiation pneumonitis (RP) is a serious complication in patients undergoing thoracic radiotherapy (TRT). Serum KL-6 and SP-D have been shown to increase in several kinds of interstitial pneumonia. To evaluate their clinical usefulness in detecting RP, we serially measured them in patients receiving TRT. Thirty-nine patients, who received TRT for lung cancer between July 1999 and April 2004, were prospectively studied. Serum levels of KL-6 and SP-D were measured using enzyme-linked immunosorbent assays. Patients were followed up until August 2004 or their deaths. During the period, RP occurred in 19 patients. In five patients with diffuse RP extended outside the radiation field, serum KL-6 levels increased, reaching more than 1,000 U/mL. Serum KL-6 levels at 40 Gy in patients who developed RP were higher than those without it (p = 0.0363, Mann-Whitney U test). In addition, serum KL-6 levels at 40 Gy in patients who developed RP were higher than those of pretreatment (p = 0.0126, Wilcoxon signed rank test). On the other hand, there were no statistical differences between sp-d at 40 Gy and those before TRT (P = 0.1165). Increased KL-6 at 40 Gy compared with those before treatment in patients undergoing TRT may be of clinical signi...Continue Reading

Citations

Oct 17, 2008·Future Oncology·Yaacov Richard LawrenceAdam P Dicker
Jan 23, 2008·The British Journal of Radiology·M NomuraK Takeda
Jul 31, 2012·Journal of Cancer Research and Clinical Oncology·Xiao-Jing ZhangZheng-Tang Chen
Sep 7, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Indira MadaniJan Van Meerbeeck
Mar 31, 2007·Seminars in Radiation Oncology·Katharina FleckensteinZeljko Vujaskovic
Sep 28, 2010·Journal of Clinical Laboratory Analysis·Kunihiko MiyazakiNobuyuki Hizawa
Jun 7, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hiromitsu IwataAkifumi Miyakawa
Sep 7, 2017·ERJ Open Research·Akihiko SokaiMichiaki Mishima
Apr 1, 2008·Cancer Control : Journal of the Moffitt Cancer Center·Feng-Ming KongTheodore S Lawrence

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