Simultaneous microfluidic spinning of multiple strands of submicron fiber for the production of free-standing porous membranes for biological application

Biofabrication
DoYeun ParkSang-Hoon Lee

Abstract

Microfibers produced using electrospinning and microfluidics-based technologies have been developed as a powerful tool in tissue engineering applications such as drug delivery and scaffolds. The applications of these fibers, however, have been limited because of the hazardous solvents used to make them, difficulties in controlling the pore sizes of their membrane forms, and downscaling the size of the fiber. Nevertheless, extending the use of these fibers, for example in the production of a free-standing porous membrane appropriate for cell-based research, is highly needed for tissue engineering, organ-on-a-chip, and drug delivery research and applications. Here, we fabricated a free-standing porous membrane by using a novel method that involved simultaneously spinning multiple strands of submicron-thick 'noodle-like' fibers. In addition to the novelty of the single noodle fiber in overcoming the size-reducing limitations of conventional microfluidic spinning methods, these fibers can hence form the units of 'noodle membranes' whose pores have sizes that the convention electrospinning method cannot achieve. We confirmed the potential of the noodle membrane to serve as a free-standing porous membrane in two simple experiments. A...Continue Reading

References

Nov 13, 2003·Electrophoresis·Samuel K Sia, George M Whitesides
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Jul 20, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Su-Jung ShinSang-Hoon Lee
Jun 3, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Chang Mo HwangSang-Hoon Lee
Jan 13, 2009·Journal of Bioscience and Bioengineering·Huihui XuRichard L Magin
Aug 15, 2009·Lab on a Chip·Jae-Hoon JungChang-Soo Lee
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
May 12, 2012·The Biochemical Journal·Kristen K McCampbell, Rebecca A Wingert
Jun 29, 2012·Advanced Materials·Edward KangSang-Hoon Lee
Oct 19, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro· KshitizDeok-Ho Kim
Nov 5, 2013·International Journal of Molecular Sciences·Muhammad Shuja KhanJohn Dalton Williams
Jan 1, 2012·Cells·Liang-I KangGeorge K Michalopoulos
Feb 2, 2016·Tissue Engineering and Regenerative Medicine·Ing Loon Sean ChuaJae Ho Lee

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