Simultaneous multislice acquisition with multi-contrast segmented EPI for separation of signal contributions in dynamic contrast-enhanced imaging

PloS One
Klaus EickelMatthias Günther

Abstract

We present a method to efficiently separate signal in magnetic resonance imaging (MRI) into a base signal S0, representing the mainly T1-weighted component without T2*-relaxation, and its T2*-weighted counterpart by the rapid acquisition of multiple contrasts for advanced pharmacokinetic modelling. This is achieved by incorporating simultaneous multislice (SMS) imaging into a multi-contrast, segmented echo planar imaging (EPI) sequence to allow extended spatial coverage, which covers larger body regions without time penalty. Simultaneous acquisition of four slices was combined with segmented EPI for fast imaging with three gradient echo times in a preclinical perfusion study. Six female domestic pigs, German-landrace or hybrid-form, were scanned for 11 minutes respectively during administration of gadolinium-based contrast agent. Influences of reconstruction methods and training data were investigated. The separation into T1- and T2*-dependent signal contributions was achieved by fitting a standard analytical model to the acquired multi-echo data. The application of SMS yielded sufficient temporal resolution for the detection of the arterial input function in major vessels, while anatomical coverage allowed perfusion analysis o...Continue Reading

References

Apr 1, 1984·British Medical Bulletin·I R Young
Oct 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A Feinberg, K Oshio
Aug 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J P Mugler, J R Brookeman
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·T MiyatiS Ohba
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E P VonkenM A Viergever
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Jan 24, 2004·Der Radiologe·R M HeidemannP M Jakob
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix A BreuerPeter M Jakob
Jul 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rexford D NewbouldRoland Bammer
Jul 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S SourbronM Peller
Jul 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix A BreuerMark A Griswold
May 1, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Steen MoellerKâmil Uğurbil
Aug 18, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lucy E Kershaw, Hai-Ling Margaret Cheng
Aug 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kawin SetsompopLawrence L Wald
Dec 8, 2011·IEEE Pulse·Felix RitterHeinz-Otto Peitgen
Jun 15, 2012·Journal of Magnetic Resonance Imaging : JMRI·Anagha DeshmaneNicole Seiberlich
Dec 21, 2012·AJR. American Journal of Roentgenology·Marco EssigMeng Law
May 16, 2013·NMR in Biomedicine·Steven P Sourbron, David L Buckley
Aug 22, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Stephen F CauleyKawin Setsompop
Oct 3, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Fernando Calamante
Nov 14, 2013·Journal of Medical Internet Research·Michael KistlerPhilippe Büchler
Nov 29, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cornelius EichnerKawin Setsompop
Sep 24, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Geon-Ho JahngFernando Calamante
Aug 27, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Markus BarthBenedikt A Poser

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Citations

Sep 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rüdiger Stirnberg, Tony Stöcker

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Software Mentioned

SMS
SG
syngio
- library
MPFIT
CAIPIRINHA
ICE
MATLAB

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