Simultaneous occurrence of infantile hemangioma and congenital melanocytic nevus: Coincidence or real association?

Journal of the American Academy of Dermatology
Peggy A WuIlona J Frieden

Abstract

Both infantile hemangiomas (IH) and congenital melanocytic nevi (CMN) are common birthmarks that affect approximately 4% to 5% of infants and 1% of newborns, respectively. No previous association has been established between these birthmarks. We report a series of 6 patients who were remarkable for either the proximity or extent of anatomic involvement of their IH and CMN. Patient 1 had a large CMN in the area of her left eye and upper face in addition to a parotid IH. Likewise, patient 5 had a giant CMN on her back and a beard distribution IH. Patients 2, 3, and 4 were found to have small CMNs and localized IH in close anatomic proximity. Patient 6 was seen for a large left parietal scalp CMN with satellite nevi and multiple cutaneous hemangiomas. Although IH and CMN are common birthmarks, the clinical characteristics in these cases suggest a real, not coincidental association. Possible pathogenetic mechanisms to explain this association are discussed.

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Citations

Feb 7, 2012·Pediatric Dermatology·Deniz A AricaSevgi Bahadir
Sep 18, 2012·Journal of the American Academy of Dermatology·Sven KrengelAshfaq A Marghoob
Dec 1, 2008·Annales de dermatologie et de vénéréologie·P Vabres
Sep 23, 2011·The Journal of Investigative Dermatology·Shoshana GreenbergerJoyce Bischoff
Jan 13, 2010·International Journal of Dermatology·Rajoo ThapaSandipan Dhar
Feb 24, 2010·The Journal of Dermatology·Hui-Jun MaDong-Guang Li
May 22, 2019·The British Journal of Dermatology·S PolubothuV A Kinsler
Aug 27, 2019·Pediatric Dermatology·Nicole W KittlerIlona J Frieden
Apr 5, 2016·The American Journal of Dermatopathology·Angel Fernandez-Flores, Marcela Saeb-Lima
Jun 9, 2016·The British Journal of Dermatology·V Martins da Silva, V Kinsler

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