Simultaneous olfactory discrimination elicits a strain-specific increase in dendritic spines in the hippocampus of inbred mice

Hippocampus
Leonardo RestivoEvelyne Marchetti

Abstract

This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus-related learning. The behavioral data first showed a clear-cut difference in performance between the two strains. C57 mice learned to identify the positively reinforced olfactory cue whereas DBA did not. Both strains, however, similarly acquired the procedural aspects of the task. The morphological analysis performed 24 h post-training revealed that spine density was significantly increased along apical, oblique, and basal dendrites in trained C57 mice compared to trained DBA mice, and to pseudotrained as well as to control cage mice of both strains. These findings confirm the ability of C57 mice to solve hippocampal-dependent tasks and provide the first evidence that simultaneous olfactory discrimination learning elicits spine growth in the mouse hippocampus. In addition, the finding that DBA mice failed to discriminate between the two olfactory cues but were as efficient as C57 mice in learning the procedural aspects of the task outlines that the struc...Continue Reading

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Citations

Dec 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leonardo RestivoMartine Ammassari-Teule
Nov 22, 2011·Behavioural Brain Research·Antonio TrabalzaArturo Bevilacqua
Mar 5, 2016·Neural Plasticity·Ossama Khalaf, Johannes Gräff
Sep 15, 2015·Behavioural Brain Research·Stéphane D GirardFrançois S Roman
Aug 14, 2009·The European Journal of Neuroscience·Takuma KitanishiNorio Matsuki
May 21, 2013·The EMBO Journal·Elisabetta MennaMichela Matteoli
Aug 19, 2014·Neurobiology of Learning and Memory·Silvia MiddeiHélène Marie
Nov 5, 2016·Neurobiology of Learning and Memory·Martine Ammassari-Teule
May 29, 2019·The International Journal of Neuropsychopharmacology·Noboru Hiroi, Takahira Yamauchi
Feb 26, 2021·Neuroscience and Biobehavioral Reviews·Maëva FerrarisPascale P Quilichini
Mar 19, 2021·Behavioural Brain Research·Guy EscoffierFrançois S Roman
Jul 21, 2012·Learning & Memory·Silvia MiddeiMartine Ammassari-Teule

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