Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer

Analytical Chemistry
Christopher J PulliamR Graham Cooks

Abstract

Advances in chemical sampling using miniature mass spectrometer technology are used to monitor slow reactions at a frequency of ca. 180 h-1 (on the Mini 12) with no sample carryover and with inline derivatization in the case of poorly ionizing compounds. Moreover, we demonstrate high reproducibility with a relative error of less than 10% for major components. Monitoring is enabled using a continuous-flow nanoelectrospray (CF-nESI) probe contained in a custom-built 3D-printed rotary holder. The holder position is automatically set using a stepper motor controlled by a microcontroller. Reaction progress of up to six reactions, including hydrazone formation and Katritzky transamination, can be monitored simultaneously without carryover for several hours.

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Citations

Dec 4, 2019·Mass Spectrometry Reviews·Przemyslaw MielczarekMarek Smoluch
Mar 9, 2018·Chemistry : a European Journal·Claudio IacobucciFrancesco De Angelis
May 24, 2021·Analytica Chimica Acta·M GrajewskiG Ij Salentijn
Aug 14, 2019·Analytical Chemistry·Veronica TermopoliChris G Gill
Oct 22, 2020·Journal of the American Society for Mass Spectrometry·Josha JagerMarco H Blokland

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