PMID: 25730974Mar 4, 2015Paper

Simultaneous opposite axonal currents in neural process. Retraction hypothesis

Biofizika
O S SotnikovS S Sergeeva

Abstract

Bidirectional axonal current of organelles and molecules in the nerve fibers was demonstrated using radioautography, the horseradish peroxidase and in virology. However, the mechanism of this phenomenon and regulation of the currents direction in axoplasm still remain not entirely understood. In this article we used the model of living single neurons of mollusk isolated with fragment of neural process at its different levels. It was proved that the axoplasm has a mechanical tone, which is realized in the form of retraction up to complete axoplasm invagination in the neuron soma. The geometry changing of the living axon was treated as its transport neuroplasm mass. It turned out that the direction of axoplasm mass depends on the location of its adhesion sites. It is always simultaneous and bidirectional opposite, as it is the case with contractile muscle fibers.

References

Nov 1, 1988·Neuron·T Mitchison, M Kirschner
Jul 19, 2005·Annual Review of Neuroscience·Liqun Luo, Dennis D M O'Leary
Oct 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christina G von der OheH Craig Heller
Nov 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ana María MagariñosPaul Pevet
Apr 1, 1948·The Journal of Experimental Zoology·P WEISS, H B HISCOE
May 23, 2009·PLoS Pathogens·Sara SalinasEric J Kremer
Dec 15, 2010·European Journal of Cell Biology·Thomas FathVelia M Fowler
Dec 22, 2010·Cell Adhesion & Migration·Justin G LeesGeraldine M O'Neill
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eun-Mi HurFeng-Quan Zhou
Feb 14, 2012·Cytoskeleton·Peter W Baas, Olga I Mozgova
Mar 16, 2012·Gene Therapy·E A SalegioK S Bankiewicz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.