Simultaneous pancreas-kidney transplantation in patients with type 1 diabetes reverses elevated MBL levels in association with MBL2 genotype and VEGF expression

Diabetologia
R BijkerkM E J Reinders

Abstract

High levels of circulating mannan-binding lectin (MBL) are associated with the development of diabetic nephropathy and hyperglycaemia-induced vasculopathy. Here, we aimed to assess the effect of glycaemic control on circulating levels of MBL and the relationship of these levels with vascular damage. We assessed MBL levels and corresponding MBL2 genotype, together with vascular endothelial growth factor (VEGF) levels as a marker of vascular damage, in type 1 diabetes patients with diabetic nephropathy before and after simultaneous pancreas-kidney (SPK) transplantation. We included diabetic nephropathy patients (n = 21), SPK patients (n = 37), healthy controls (n = 19), type 1 diabetes patients (n = 15) and diabetic nephropathy patients receiving only a kidney transplant (n = 15). Fourteen diabetic nephropathy patients were followed up for 12 months after SPK. We found elevated circulating MBL levels in diabetic nephropathy patients, and a trend towards elevated circulating MBL levels in type 1 diabetes patients, compared with healthy control individuals. MBL levels in SPK patients completely normalised and our data indicate that this predominantly occurs in patients with a polymorphism in the MBL2 gene. By contrast, MBL levels i...Continue Reading

References

Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Stefan P BergerJohan W de Fijter
Nov 8, 2008·Current Diabetes Reports·Sheldon Chen, Fuad N Ziyadeh
May 27, 2010·Diabetes/metabolism Research and Reviews·Juliette FortpiedEmile Van Schaftingen
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Feb 26, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M KhairounM E J Reinders
Feb 27, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R BijkerkM E J Reinders

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Citations

Oct 18, 2016·Current Opinion in Nephrology and Hypertension·Erik StitesAlexander C Wiseman
Mar 7, 2017·Nature Reviews. Nephrology·Allan Flyvbjerg
Jan 11, 2018·Journal of Diabetes Research·Gry Høst DørflingerTroels Krarup Hansen
Mar 7, 2020·Journal of Zhejiang University. Science. B·Zhi-Feng ZhouJin-Lei Lv
May 1, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Koen E GroenewegRoel Bijkerk
Feb 9, 2021·British Journal of Pharmacology·Didier Portilla, Sandhya Xavier

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Methods Mentioned

BETA
genotyping
ELISA

Software Mentioned

SPSS
GraphPad Prism

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