Simultaneous protection and activation of amino acids using propargyl pentafluorophenyl carbonate

Organic Letters
Ramapanicker RameshSrinivasan Chandrasekaran

Abstract

[reaction: see text] A very efficient method for the simultaneous protection of the amino group and activation of the carboxyl group of amino acids is reported using propargyl pentafluorophenyl carbonate (PocOPfp). The amino group is protected as a propargyloxycarbonyl (Poc) derivative, and the carboxyl group is activated as a pentafluorophenyl ester. The yields obtained are good to excellent ranging from 60 to 87%.

Citations

Oct 27, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Ramesh RamapanickerSrinivasan Chandrasekaran
Jul 14, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Srinivasan Chandrasekaran, Ramesh Ramapanicker
Jan 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yahya El-Sayed JadFernando Albericio
Feb 14, 2020·ACS Synthetic Biology·Christopher M ScheidlerSabine Schneider

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