Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis - effects of age and disease duration

Arthritis Research & Therapy
David SimonGeorg Schett

Abstract

Comprehensive simultaneous quantification of bone erosion and enthesiophytes in the joints of patients with psoriatic arthritis (PsA) has not been performed. Herein, we aimed to compare the extent of bone erosion and enthesiophytes in patients with PsA, psoriasis (PSO) and healthy controls, assess the influence of age and disease duration on the development of erosions and enthesiophytes and define their impact on physical function. Patients with PsA or with PSO and controls were analysed by high-resolution peripheral quantitative computed tomography (HR-pQCT). The extent of bone erosions and enthesiophytes was assessed and plotted according to different categories of age, duration of PSO and duration of PsA, respectively. In addition, demographic and disease-specific data, including physical function (health assessment questionnaire) were collected. A total of 203 patients were analysed; 101 had PsA, 55 had PSO and 47 were healthy individuals. Patients with PsA had significantly more and larger erosions (p = 0.002/p = 0.003) and enthesiophytes (p < 0.001) compared to patients with PSO and healthy controls. Patients with PSO and healthy controls did not differ in erosions, while enthesiophytes were more frequent in patients wit...Continue Reading

References

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Citations

Dec 12, 2019·Zeitschrift für Rheumatologie·X BaraliakosP Sewerin
Mar 5, 2020·Expert Opinion on Biological Therapy·Maurizio RossiniAnnamaria Iagnocco
Sep 5, 2020·Rheumatology·Axel P VillaniCyrille B Confavreux
Sep 30, 2020·Seminars in Musculoskeletal Radiology·Chiara GiraudoSiegfried Trattnig
Jan 16, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D WuL-S Tam
Nov 17, 2020·Frontiers in Medicine·Angelo FassioLuca Idolazzi
Apr 1, 2021·Rheumatology·Yannick DegboéCarl S Goodyear
Jul 1, 2021·Experimental Dermatology·Claudio LemboAnna Balato

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Software Mentioned

PSO
Osirix
SPSS

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