Simultaneous quantification of digoxin, digitoxin, and their metabolites in serum using high performance liquid chromatography-tandem mass spectrometry

Drug Testing and Analysis
Caroline ByldaDietrich A Volmer

Abstract

The study describes an LC-MS/MS method for simultaneous quantification of the cardiac glycosidic drugs digoxin and digitoxin and several of their metabolites. The assay represents a useful reference method for immunoassay-based tests, which are easily biased by the presence of metabolites of the target analytes or structurally similar substances.

References

Jan 1, 1977·Clinical Pharmacokinetics·E Iisalo
Feb 1, 1977·Journal of Pharmaceutical Sciences·P H HinderlingR D Wester
Feb 15, 1972·Klinische Wochenschrift·A Ruiz-Torres, H Burmeister
Dec 1, 1970·The Journal of Clinical Investigation·T W Smith, E Haber
Dec 1, 1996·Current Problems in Cardiology·S H Rahimtoola, T Tak
Jan 30, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Cara PolsonRussell Grant
Feb 18, 2003·JAMA : the Journal of the American Medical Association·Saif S RathoreHarlan M Krumholz
Dec 17, 2004·Molecular Pharmacology·Peter KometianiAmir Askari
Feb 25, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·James L LittleCharles M Buchanan
Jun 1, 2006·Circulation·Mihai GheorghiadeWilson S Colucci
Jun 15, 2007·International Journal of Legal Medicine·L FrommherzJ Beike
Aug 2, 2007·Expert Opinion on Therapeutic Targets·Miguel López-Lázaro
Oct 3, 2009·Journal of Analytical Toxicology·Elisabeth Leere OiestadAsbjørg Solberg Christophersen
Nov 16, 2010·Analytical and Bioanalytical Chemistry·Sanae KannoOsamu Suzuki
Jul 22, 2011·International Journal of Analytical Chemistry·Paula MeloHelena M Teixeira
Nov 1, 2011·Toxicology and Applied Pharmacology·Hosam A ElbazYon Rojanasakul
Oct 3, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Romana UřinovskáMilan Grundmann
Dec 6, 2012·Experimental Hematology & Oncology·Hosam A ElbazCerasela Zoica Dinu

❮ Previous
Next ❯

Citations

May 11, 2016·Clinical Biochemistry·Maria Shipkova, Dobrin Svinarov
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuela CortesePiera Di Di Martino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.