Apr 13, 2011

Simultaneous release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus described by dimensionless equations

Acta poloniae pharmaceutica
Regina Kasperek

Abstract

The release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus was studied. The influence of excipients and of a size of the solid dosage forms on the amount of the released substances at the intervals of time using the different rates of flow of the dissolution medium was investigated. Physical parameters corresponding to the dissolution process as the mass transfer coefficient, the thickness of the boundary diffusion layer and the concentration of the saturated solution at this layer were calculated. The results of release were described by dimensionless equations.

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Mentioned in this Paper

Pavatym
Drug Formulation Process
Diclonate P
Microencapsulation
Diclofenac Sodium
Pharmaceutical Excipient
Papaverine Hydrochloride
Technology, Pharmaceutical
Drug Combinations

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