Simultaneous sensitivity to fragrances.

The British Journal of Dermatology
D A BuckleyJ P McFadden

Abstract

Cinnamal/cinnamic alcohol and isoeugenol/eugenol are pairs of related fragrance chemicals found in Fragrance Mix I (FM I), and thus are routinely tested in combination with other fragrances in the European standard patch test series. Their close structural similarity makes the occurrence of simultaneous sensitivity within these chemical pairs likely, although at present there are no robust data to support this hypothesis. To establish the frequency of simultaneous reactions to these fragrance chemicals in patients with suspected fragrance allergy attending a contact dermatitis clinic; to provide evidence in support of proposed metabolic pathways; and to determine whether including all four separately in FM I is necessary to avoid missing a diagnosis of fragrance allergy. We analysed retrospectively the records of patients patch tested to the European standard series during the 15-year period 1984-98 for positive reactions to FM I. In a subset of patients tested to the constituents of FM I, positive reactions to cinnamal, cinnamic alcohol, isoeugenol and eugenol were sought. Data were analysed using 2x2 contingency tables (Fisher's exact test). During this period, 23,660 patients were tested to the European standard series, of w...Continue Reading

References

Sep 1, 1991·Contact Dermatitis·D A Basketter, C F Allenby
Jan 1, 1995·Contact Dermatitis·J D Johansen, T Menné
Sep 1, 1996·The British Journal of Dermatology·J D JohansenT Menné
Mar 24, 2000·The British Journal of Dermatology·D A BuckleyJ P McFadden
Oct 24, 2000·Toxicology and Applied Pharmacology·C K SmithS A Hotchkiss
Sep 13, 2002·Contact Dermatitis·W G Larsen
Mar 5, 2003·Journal of Dermatological Science·Connie CheungCamilla K Smith Pease
Mar 18, 2004·Chemical Research in Toxicology·Eiram N ElahiCamilla K Smith Pease

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Citations

Jun 15, 2007·Regulatory Toxicology and Pharmacology : RTP·Anne Marie ApiWilliam Troy
Feb 12, 2009·Contact Dermatitis·Leena AckermannKristiina Alanko
Jun 19, 2007·The British Journal of Dermatology·D A Buckley
Sep 19, 2014·Contact Dermatitis·Martin MowitzMagnus Bruze
Nov 16, 2018·Contact Dermatitis·Juan F SilvestreVirginia Fernández-Redondo
Jan 28, 2014·Chemical Research in Toxicology·Ida B NiklassonAnn-Therese Karlberg

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