Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis

Electrophoresis
Shanshan ZhouJin Ouyang

Abstract

The analysis is described for separating seven beta-adrenergic blocking agents (atenolol, celiprolol, clorprenaline, fenoterol, metoprolol, propranolol, terbutaline) and clenbuterol (sympathomimetic beta-2 receptor stimulating agonist, decongestant and bronchodilator, illicit anabolic used in athletics) by CE with UV detection. In order to simultaneously separate all analytes, Tris-H3PO4 solution was applied containing titanium dioxide nanoparticles (TiO2 NPs) as BGEs. The effects of important factors, such as concentration of TiO2 NPs, optimum pH, run buffer concentration, and separation voltage, were investigated so as to achieve best CE separation. The eight analytes could be well separated applying a separation voltage of 15 kV in 75 mM Tris-H3PO4 buffer at a pH of 2.40, containing 6.0 x 10(-6) g/mL TiO2 NPs. Under these optimal conditions, the RSDs for peak areas and for migration times were less than 2.7 and 2.3%, respectively. The detection limits were 0.1 microg/mL for celiprolol, 0.1 microg/mL for propranolol, 0.2 microg/mL for fenoterol, 1.0 microg/mL for atenolol, 1.0 microg/mL for clenbuterol, 1.0 microg/mL for clorprenaline, 1.0 microg/mL for metoprolol, and 1.0 microg/mL for terbutaline. The proposed method was su...Continue Reading

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Citations

May 4, 2010·Analytical and Bioanalytical Chemistry·Leena Suntornsuk
Jul 10, 2014·The Analyst·Sheng TangShengxiang Jiang
May 1, 2009·Bioanalysis·Maria K ParrWilhelm Schänzer
Jul 14, 2017·Electrophoresis·Vojtech Adam, Marketa Vaculovicova
Mar 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ankur GogoiGuan-Yu Zhuo
Mar 2, 2021·Chirality·Hassan Y Aboul-EneinHebatallah Wagdy
May 26, 2010·Analytical Chemistry·Nicholas W FrostMichael T Bowser

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