Simultaneous translocation of both TCR Loci (14q11) with rare partner loci (Xq22 and 12p13) in a case of T-lymphoblastic leukemia.

Annals of Laboratory Medicine
Dong-Hee KangByung Ryul Jeon

Abstract

The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve T-cell receptor (TCR) loci and a variety of partner genes, including HOX11, HOX11L2, MYC, and TAL1. In this report, we present a rare case involving simultaneous translocation of the TCR α/δ loci with different partner loci (Xq22 and 12p13); this resulted in a poor prognosis. Chromosomal analysis showed 46,Y,t(X;14)(q22;q11.2),t(12;14)(p13;q11.2) and FISH analysis by using a T-cell receptor alpha delta DNA probe, Split Signal (DakoCytomation, Denmark), showed translocations at the same TCR α/δ locus on both chromosomes. FISH with 2 bacterial artificial chromosome clones showed break apart signal, which suggests involvement of the IRS4 gene. To our knowledge, this is the first report of T-ALL in which both TCR α/δ loci were translocated with different partner loci, and 1 of the partner loci, Xq22, was a rare translocation partner locus that included IRS4 gene.

References

Oct 1, 1990·Cancer Genetics and Cytogenetics·T InabaN Fujita
Jul 15, 1999·Biochemical and Biophysical Research Communications·V R FantinL M Wang
Apr 23, 2004·Leukemia & Lymphoma·Nathalie Douet-GuilbertMarc De Braekeleer
Aug 12, 2008·British Journal of Haematology·Pieter Van VlierbergheJules P P Meijerink
Feb 3, 2009·Haematologica·Sabina Chiaretti, Robin Foà
Mar 27, 2010·International Journal of Cancer. Journal International Du Cancer·Fredrik MertensMaria Debiec-Rychter

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Citations

Oct 2, 2019·Cold Spring Harbor Perspectives in Medicine·Francesca GianniAdolfo Ferrando

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Methods Mentioned

BETA
biopsy

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