Simultaneous type 1 diabetes onset in mother and son coincident with an enteroviral infection

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Maria HinderssonFrisk Gun

Abstract

Enterovirus (EV) infections have been implicated in the development of type 1 diabetes. (T1D). They may cause beta-cell destruction either by cytolytic infection of the cells or indirectly by triggering the autoimmune response. Virus was isolated from a woman at diagnosis of T1D (Tuvemo 1) and in addition, virus was isolated from her son at diagnosis of T1D at the same day (Tuvemo 2). None of the isolates could initially be serotyped by conventional methods. The Tuvemo 1 virus was genotyped and after sub-cultivation it was also serotyped as Coxsackievirus B5. The mother revealed antibodies against GAD65. The boy and the father both revealed a significant increase in neutralization antibody titre against two strains of CBV-4, clearly indicating a recent or ongoing EV infection. In addition, the brother showed such a titre rise against another CBV-4 strain (E2) and against a CBV-5 strain (4429). These results show that the whole family had a proven EV infection at the time of T1D diagnosis of the mother and the 10-years-old boy, indicating that the infection might cause or accelerate the T1D.

References

Apr 16, 1977·British Medical Journal·C WilsonD Thomson
Mar 1, 1989·The Journal of Clinical Investigation·M J SheehyB S Nepom
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G T HornH A Erlich
Jan 1, 1985·Scandinavian Journal of Infectious Diseases·B S NiklassonE Möller
Sep 13, 1969·British Medical Journal·D R GambleK W Taylor
Sep 13, 1969·British Medical Journal·D R Gamble, K W Taylor
Sep 1, 1982·The Journal of Pediatrics·C M AsplinJ P Palmer
May 1, 1983·The Journal of Pediatrics·F KurtzG R Hauptmann
Nov 24, 1994·The New England Journal of Medicine·M A Atkinson, N K Maclaren
May 3, 1996·Cell·R Tisch, H McDevitt
Aug 1, 1996·The Journal of General Virology·T PöyryG Stanway
Jun 3, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·M LönnrotH Hyöty
May 6, 1999·The Journal of Infectious Diseases·J M Groarke, D C Pevear
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G R VreugdenhilJ M Galama
Feb 26, 2003·Journal of Medical Virology·Anja PaananenMerja Roivainen

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Citations

Jan 5, 2007·Reviews in Endocrine & Metabolic Disorders·Hui Peng, William Hagopian
May 16, 2006·Journal of Virology·Toru KannoSteven Tracy
Apr 29, 2010·Seminars in Immunopathology·Sarah J RichardsonAlan K Foulis
Feb 3, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Danny Zipris
Jul 22, 2009·Diabetes/metabolism Research and Reviews·H JaïdaneD Hober
Mar 23, 2007·Annals of the New York Academy of Sciences·Steven Tracy, Kristen M Drescher
Mar 23, 2013·Pediatric Diabetes·Maria E CraigWilliam D Rawlinson
Jul 22, 2010·Journal of Medical Virology·Anna-Karin BergGun Frisk
Jan 6, 2010·Reviews in Medical Virology·S TracyK Kono
Aug 12, 2014·Journal of Medical Virology·Steven TracyNora Chapman
Nov 29, 2014·Reviews in Medical Virology·Kristen M DrescherSteven Tracy
Jun 15, 2007·Virology·Monica HultcrantzMalin Flodström-Tullberg
Jan 24, 2007·Antiviral Research·Anna-Karin BergGun Frisk
Oct 16, 2007·Journal of Medical Virology·A ElfaitouriJ Blomberg

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