Simultaneous up-regulation of neurofilament proteins during the postnatal development of the rat nervous system

Journal of Neuroscience Research
W W Schlaepfer, J Bruce

Abstract

The expression of neurofilament (NF) proteins was examined during postnatal development of the rat nervous system in order to elucidate the nature of NF expression during the period of transition from the embryonic (immature) to the adult (mature) stages of NF expression. mRNAs to the light (NF-L), mid-sized (NF-M), and heavy (NF-H) NF proteins were compared by Northern blots and by in situ hybridizations, in NF-rich (i.e., DRG, spinal cord and brainstem) and in NF-poor (i.e., cerebellum and cerebral cortex) regions of the developing rat nervous system. NF proteins were analyzed by gel electrophoresis and by immunoblots. In each tissue, the expression of NF-H was delayed compared to that of NF-L and NF-M, as previously reported. The present study now shows that the delayed expression of NF-H is accompanied by parallel up-regulations in the expressions of NF-L and NF-M, both at the levels of mRNA and protein. Similar rates of increase of all three NF mRNAs occur between postnatal days 5 (P5) and 24 (P24) in rat spinal cord and DRG. Furthermore, the postnatal up-regulation of NF expression is characterized by a progressive accumulation of all three NF proteins in the tissues. The findings indicate that the adult pattern of NF exp...Continue Reading

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Citations

Sep 1, 1992·Journal of Neuroscience Research·M D RobersonP Morell
Dec 1, 1992·Journal of Neuroscience Research·M AraiJ A Cohen
Jun 15, 1995·Journal of Neuroscience Research·I M ParhadA W Clark
Jan 1, 1997·Virchows Archiv : an International Journal of Pathology·T SugimotoJ Hata
Mar 1, 1992·Brain Research. Molecular Brain Research·P S ShneidmanW W Schlaepfer
Mar 1, 1993·Brain Research. Molecular Brain Research·J BruceW W Schlaepfer
Dec 1, 1994·Brain Research. Molecular Brain Research·M L SchwartzW W Schlaepfer
Jun 1, 1996·Brain Research. Molecular Brain Research·R Pernas-AlonsoU di Porzio
Mar 17, 2004·Biochemical and Biophysical Research Communications·Michael J StrongWei-Wen Ge
Apr 18, 2002·Journal of the Neurological Sciences·Catherine FressinaudFrederic Dubas
Jun 5, 2003·Pharmacology & Therapeutics·Michael J Strong
Sep 23, 2003·Brain Research. Molecular Brain Research·Junhua WuRafaela Cañete-Soler
Jun 19, 1998·Brain Research. Molecular Brain Research·M L SchwartzW W Schlaepfer
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Jun 20, 1998·The Journal of Biological Chemistry·R Cañete-SolerW W Schlaepfer
Nov 3, 1995·The Journal of Biological Chemistry·M L SchwartzW W Schlaepfer

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