Simultaneous very low dose mifepristone and vaginal misoprostol for medical abortion

Contraception
Nathalie KappPhillip Stubblefield

Abstract

This pilot study was designed to evaluate the outcome of medical abortion following simultaneous mifepristone (100 mg) and misoprostol (800 microg). Enrollees had gestational ages up to 56 days and desired a medical abortion. They received 100 mg of mifepristone orally and 800 microg of misoprostol vaginally. Follow-up examination occurred in 2-7 days. A phone call 3 weeks later assessed symptoms and acceptability. A 95% success rate, as seen in higher dose studies, gives a 95% confidence interval of 88-100% for 40 subjects. Forty women were enrolled; 39 women had follow-up visits. Completed medical abortion was confirmed for 35 (90%) of 39 women. Four women had uterine aspiration. Two patients required repeat misoprostol. Median time from medication to abortion was 7 h. Most women (92%) strongly preferred taking all medications in the clinic. The simultaneous administration of vaginal misoprostol with 100 mg of oral mifepristone had the outcome of completed abortion within the predicted confidence interval. In addition, simultaneous dosing was highly acceptable.

References

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Citations

Dec 17, 2009·Contraception·Eric A Schaff
Nov 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yayi SunZhiying Hu
Dec 13, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Oi Shan Tang, Pak Chung Ho
Mar 13, 2018·Obstetrics and Gynecology·Patricia A LohrAbigail R A Aiken
Jul 6, 2018·The Journal of Obstetrics and Gynaecology Research·Li-Ping SongXue-Tang Mo
Jul 5, 2007·The Journal of Family Planning and Reproductive Health Care·Cathy Tupper, Shonagh Speed Andrews
Jan 21, 2019·The Cochrane Database of Systematic Reviews·Jie ShenLinan Cheng
Mar 10, 2020·The Cochrane Database of Systematic Reviews·Katherine GambirThoai D Ngo
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology

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