Simultaneous Visualization of Multiple mRNAs and Matrix Metalloproteinases in Living Cells Using a Fluorescence Nanoprobe

Chemistry : a European Journal
Wei PanBo Tang

Abstract

Simultaneous monitoring of multiple tumour markers is of great significance for improving the accuracy of early cancer detection. In this study, a fluorescence nanoprobe has been prepared that can simultaneously monitor and visualize multiple mRNAs and matrix metalloproteinases (MMPs) in living cells. Confocal fluorescence imaging results indicate that the nanoprobe could effectively distinguish between cancer cells and normal cells even if one tumour maker of normal cells was overexpressed. Furthermore, it can detect changes in the expression levels of mRNAs and MMPs in living cells. The current approach could provide new tools for early cancer detection and monitoring the changes in expression levels of biomarkers during tumour progression.

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Citations

Mar 28, 2017·Chemical Society Reviews·Yuqiong XiaXiaoyuan Chen
Jun 27, 2017·Chemical Communications : Chem Comm·Tao XieYi-Tao Long
Mar 8, 2017·Organic & Biomolecular Chemistry·Sylvain Debieu, Anthony Romieu
Jul 5, 2019·Advanced Materials·Devleena SamantaChad A Mirkin
Aug 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Christian WirajaChenjie Xu
May 1, 2016·Chemical Science·Xiang-Ling LiHong-Yuan Chen
Dec 14, 2018·Chemical Science·Xiangdan MengXueji Zhang
Dec 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dinggeng HeHung-Wing Li
Jun 11, 2020·Analytical Chemistry·Peng GaoBo Tang

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