Simultaneous visualization of tumour oxygenation, neovascularization and contrast agent perfusion by real-time three-dimensional optoacoustic tomography

European Radiology
Vladimir ErmolayevDaniel Razansky

Abstract

Intravital imaging within heterogenic solid tumours is important for understanding blood perfusion profiles responsible for establishment of multiple parameters within the tumour mass, such as hypoxic and nutrition gradients, cell viability, proliferation and drug response potentials. Herein, we developed a method based on a volumetric multispectral optoacoustic tomography (vMSOT) for cancer imaging in preclinical models and explored its capacity for three-dimensional imaging of anatomic, vascular and functional tumour profiles in real time. In contrast to methods based on cross-sectional (2D) image acquisition as a basis for 3D rendering, vMSOT has attained concurrent observations from the entire tumour volume at 10 volumetric frames per second. This truly four dimensional imaging performance has enabled here the simultaneous assessment of blood oxygenation gradients and vascularization in solid breast tumours and revealed different types of blood perfusion profiles in-vivo. The newly introduced capacity for high-resolution three-dimensional tracking of fast tumour perfusion suggests vMSOT as a powerful method in preclinical cancer research and theranostics. As the imaging setup can be equally operated in both stationary and h...Continue Reading

References

Jan 6, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·F C GalmariniD Galmarini
Jan 23, 2004·Nature Reviews. Cancer·John Condeelis, Jeffrey E Segall
Sep 27, 2007·Journal of the National Cancer Institute·Olivier TrédanIan F Tannock
Nov 7, 2008·Nature Reviews. Cancer·Jessica A BertoutM Celeste Simon
Jan 12, 2010·Journal of Biomedical Optics·Hans-Peter BrechtAlexander A Oraevsky
Apr 15, 2010·Chemical Reviews·Vasilis Ntziachristos, Daniel Razansky
Jul 17, 2010·Optics Letters·Andreas BuehlerVasilis Ntziachristos
Sep 15, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Athanasios SarantopoulosVasilis Ntziachristos
Jul 2, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Daniel RazanskyVasilis Ntziachristos
Jul 9, 2011·Nature Protocols·Daniel RazanskyVasilis Ntziachristos
Feb 16, 2012·IEEE Transactions on Medical Imaging·X Luís Dean-BenDaniel Razansky
Apr 21, 2012·Radiology·Eva HerzogVasilis Ntziachristos
May 23, 2012·Journal of Biomedical Optics·Jun XiaLihong V Wang
May 23, 2012·Journal of Biomedical Optics·Jan LauferPaul Beard
Feb 12, 2013·The EMBO Journal·Sarah-Jane DawsonCarlos Caldas
May 15, 2013·Physics in Medicine and Biology·Steven L Jacques
May 25, 2013·AJR. American Journal of Roentgenology·Silaja YittaNola M Hylton
Jul 19, 2013·Journal of Biomedical Optics·Daniel QueirósVasilis Ntziachristos
Aug 8, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BosettiC La Vecchia
Sep 24, 2013·IEEE Transactions on Medical Imaging·Andreas BuehlerVasilis Ntziachristos
Oct 1, 2013·Journal of Photochemistry and Photobiology. B, Biology·Hamad S AlshetaiwiDeryl L Troyer
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mohammadreza NasiriavanakiLihong V Wang
Mar 1, 2013·Photoacoustics·Adrian TaruttisVasilis Ntziachristos
May 13, 2015·Journal of Biophotonics·X Luís Deán-BenDaniel Razansky
Jul 23, 2015·Theranostics·Lorenz KirscherAladar A Szalay

❮ Previous
Next ❯

Citations

Apr 8, 2017·Chemical Communications : Chem Comm·Vipul GujratiVasilis Ntziachristos
Feb 1, 2019·Journal of Biophotonics·Benedict Mc LarneyDaniel Razansky
Dec 2, 2017·Advanced Healthcare Materials·Alexander S TiminGleb B Sukhorukov
May 16, 2018·Biomedical Optics Express·Zhenyue ChenDaniel Razansky
Jul 1, 2020·Annals of Biomedical Engineering·Paolo ZaffinoMaria Francesca Spadea
Apr 18, 2019·Nature Biomedical Engineering·Sven GottschalkDaniel Razansky
Mar 10, 2017·Chemical Society Reviews·X L Deán-BenD Razansky
Sep 26, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·S Peter JohnsonR Barbara Pedley
Jan 14, 2021·Arthritis Research & Therapy·Khalid DaoudiChris L de Korte
Mar 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hui-Chao ZhouZonghai Sheng
Feb 20, 2018··Hernan Lopez-SchierXosé Luís Deán-Ben

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.