PMID: 6162109Feb 19, 1981Paper

Simultaneous yet independent inheritance of somatically acquired tolerance to two distinct H-2 antigenic haplotype determinants in mice

Nature
R M Gorczynski, E J Steele

Abstract

We have previously presented evidence that somatically acquired immunological tolerance to foreign histocompatibility antigens induced in male inbred mice can be transmitted at a high frequency to first- and second-generation offspring without exposure of the progeny to the tolerizing antigenic stimulus. These data have in turn been interpreted to support a hypothesis predicting soma to germ-line inheritance for acquired states of the immune system. Formal proof of this genetic scheme at the molecular level is not yet available. However, an even stronger reason for abandoning the notion of the isolation of the germ line from the soma (Weismann's doctrine) would be provided by a clear demonstration of the multiple inheritance of independently acquired somatic characters. Here we present evidence that individual male mice (B10) made tolerant to two different H-2 haplotypes (B10.BR, B10.D2) can transmit the tolerance state to each haplotype independently, yet often simultaneously, at a high frequency to both first and second generation progeny.

References

Jun 11, 1976·Science·H M Temin
Jan 1, 1978·Scandinavian Journal of Immunology·R M GroczynskiJ E Till
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R M Gorczynski, E J Steele
Jan 1, 1971·European Journal of Immunology·N K Jerne

❮ Previous
Next ❯

Citations

Jan 1, 1985·Immunogenetics·C A Cooper-WillisG A Leslie
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E Nisbet-Brown, T G Wegmann
Nov 17, 1984·British Medical Journal·K Ikwueke
Jan 1, 1989·Molecular Reproduction and Development·E J Steele
Mar 1, 2006·Experimental Neurology·Peter LohmannMatthias W Riepe
Mar 11, 2006·Medical Hypotheses·Julio Lazaro Padron Velazquez
Oct 11, 2013·FEMS Microbiology Letters·Simon Silver
Mar 26, 1981·Nature·K W Jones
Dec 4, 2019·Scandinavian Journal of Immunology·Edward J Steele, Robyn A Lindley
Nov 1, 1982·Evolution; International Journal of Organic Evolution·Walter M Fitch
Oct 15, 1981·International Journal of Cancer. Journal International Du Cancer·L TomatisV Ponomarkov
Aug 26, 2019·Progress in Biophysics and Molecular Biology·Edward J SteeleN Chandra Wickramasinghe
Dec 21, 1990·Journal of Theoretical Biology·T D Johnston, G Gottlieb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.