Simultaneously activating highly selective ratiometric MRI and synergistic therapy in response to intratumoral oxidability and acidity

Biomaterials
Yuxin LiuJing Zhou

Abstract

Low selectivity is a major problem for cancer theranostics that has promoted the development of molecularly-responsive nanomaterials. Herein, we report a novel doxorubicin (DOX)-loaded degradable cobalt oxide nanoprism (Co3O4-DOX) for T1/T2 ratiometric magnetic resonance imaging (MRI)-monitored synergistic cancer therapy that simultaneously responds to intratumoral oxidability and acidity. Co3O4-DOX degraded under both H2O2-rich and acidic conditions, producing Co3+ and releasing DOX, not only resulted in an MRI contrast switch from T2 to T1, but also led to DOX luminescence recovery by weakening energy transfer. Thus, highly sensitive and selective H2O2 detection was achieved by these changes in MRI and luminescence signals. Importantly, Co3O4-DOX showed outstanding T1/T2 ratiometric MRI performance in vivo, significantly improving the contrast between tumor and normal tissues. Moreover, the produced Co3+ also resulted in intracellular radical generation for chemodynamic therapy, which had a synergistic effect with the photothermal and chemotherapy induced by Co3O4 and DOX, respectively. Under ratiometric MRI guidance, successful synergistic cancer therapy was performed on a tumor-bearing mice model. This work provides a new i...Continue Reading

Citations

Jan 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liang YanMin Wei
Jan 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nikola Ž KneŽevićJean-Olivier Durand
Jan 26, 2021·Chemical Reviews·Zhongmin TangWenbo Bu
May 9, 2021·Colloids and Surfaces. B, Biointerfaces·Marhaba MamatSong Shen
Jun 23, 2021·Chemical Society Reviews·Xianwen WangLiang Cheng
Jan 19, 2021·ACS Biomaterials Science & Engineering·Xiao LiuHaijun Yu
Nov 25, 2020·Inorganic Chemistry·Xia-Juan HuangJian-Jun Chen
Apr 23, 2020·Bioconjugate Chemistry·Yu HanJinchao Zhang
Mar 9, 2021·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Huiwen ZhangJuan Wang

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