Simultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens.

Chemical Science
Ji QiBen Zhong Tang

Abstract

Organic near-infrared (NIR) emitters hold great promise for biomedical applications. Yet, most organic NIR fluorophores face the limitations of short emission wavelengths, low brightness, unsatisfactory processability, and the aggregation-caused quenching effect. Therefore, development of effective molecular design strategies to improve these important properties at the same time is a highly pursued topic, but very challenging. Herein, aggregation-induced emission luminogens (AIEgens) are employed as substituents to simultaneously extend the conjugation length, boost the fluorescence quantum yield, and increase the solubility of organic NIR fluorophores, being favourable for biological applications. A series of donor-acceptor type compounds with different substituent groups (i.e., hydrogen, phenyl, and tetraphenylethene (TPE)) are synthesized and investigated. Compared to the other two analogs, MTPE-TP3 with TPE substituents exhibits the reddest fluorescence, highest brightness, and best solubility. Both the conjugated structure and twisted conformation of TPE groups endow the resulting compounds with improved fluorescence properties and processability for biomedical applications. The in vitro and in vivo applications reveal th...Continue Reading

References

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Methods Mentioned

BETA
fluorescence imaging
nanoprecipitation
dynamic
transmission electron microscopy
Fluorescence
fluorescence cell imaging
column chromatography
confocal microscopy
xenograft

Software Mentioned

Gaussian 09

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