Simultaneously estimating the task-related and stimulus-evoked components of hemodynamic imaging measurements

Neurophotonics
Max Charles HermanAniruddha Das

Abstract

Task-related hemodynamic responses contribute prominently to functional magnetic resonance imaging (fMRI) recordings. They reflect behaviorally important brain states, such as arousal and attention, and can dominate stimulus-evoked responses, yet they remain poorly understood. To help characterize these responses, we present a method for parametrically estimating both stimulus-evoked and task-related components of hemodynamic responses from subjects engaged in temporally predictable tasks. The stimulus-evoked component is modeled by convolving a hemodynamic response function (HRF) kernel with spiking. The task-related component is modeled by convolving a Fourier-series task-related function (TRF) kernel with task timing. We fit this model with simultaneous electrode recordings and intrinsic-signal optical imaging from the primary visual cortex of alert, task-engaged monkeys. With high [Formula: see text], the model returns HRFs that are consistent across experiments and recording sites for a given animal and TRFs that entrain to task timing independent of stimulation or local spiking. When the task schedule conflicts with that of stimulation, the TRF remains locked to the task emphasizing its behavioral origins. The current app...Continue Reading

References

Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·D MalonekA Grinvald
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M NemotoH Abe
Jun 22, 2000·Nature Neuroscience·D J HeegerD G Albrecht
Dec 29, 2000·Physics in Medicine and Biology·M KohlU Dirnagl
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
May 15, 2002·Journal of Neuroscience Methods·Amos Arieli, Amiram Grinvald
May 27, 2003·Neuron·Valery A Kalatsky, Michael P Stryker
Aug 17, 1962·Science·B CHANCEB SCHOENER
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sameer A ShethArthur W Toga
Oct 7, 2004·Brain Research. Cognitive Brain Research·Jennifer T Coull
Mar 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anna DevorAnders M Dale
Mar 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sameer A ShethArthur W Toga
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ivo VanzettaAmiram Grinvald
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Aneurin J KennerleyJohn E Mayhew
Aug 16, 2005·NeuroImage·Torben E LundThomas E Nichols
Nov 13, 2007·Journal of Biomedical Optics·Elizabeth M C Hillman
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias H DonnerDavid J Heeger
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
Oct 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yevgeniy B SirotinAniruddha Das
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcus E Raichle

❮ Previous
Next ❯

Citations

Apr 20, 2019·PLoS Biology·Mariana M B CardosoAniruddha Das
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Aniruddha DasPatrick J Drew
Jun 15, 2021·PLoS Computational Biology·Ali-Kemal AydinDavide Boido

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.