Simultaneously Load and Extended Release of Betamethasone and Ciprofloxacin from Vitamin E-Loaded Silicone-Based Soft Contact Lenses

Current Eye Research
Maryam Shayani Rad, Seyed Ahmad Mohajeri

Abstract

The purpose of the present study was to evaluate the efficacy of commercial soft contact lenses, loaded with vitamin E, as ocular drug delivery systems for simultaneous loading and release of ciprofloxacin (Cipro) and betamethasone (BMZ) in artificial tears. In this study, we applied vitamin E as a barrier to increase BMZ-Cipro loading into three commercial silicone-based soft contact lenses and control their simultaneous release into the artificial lachrymal fluid. Two different concentrations of vitamin E solution (0.1 and 0.2 g/ml) were used, and various parameters including changes in lens diameter, water content, ultraviolet-visible light (UV-Vis) transmittance, drug-binding properties, and drug release profile were investigated. The obtained results indicated that vitamin E significantly reduced the swelling properties of contact lenses in aqueous media, while it enhanced the lens diameter in both dry and hydrated states. Vitamin E had no significant effects on visible transmittance, while it blocked UV radiation, which could be harmful for the eye surface. Our findings revealed that vitamin E improved the simultaneous loading amount of BMZ-Cipro into soft contact lenses. Additionally, BMZ and Cipro release rates signific...Continue Reading

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Citations

Aug 21, 2016·The Science of the Total Environment·Chiqian ZhangShashikanth Gajaraj
Aug 28, 2020·Acta Biomaterialia·Xin FanAllan E David
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Lyndon JonesMark Willcox
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Guihua FangBo Tang

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