Simvastatin attenuates testicular injury induced by torsion-detorsion

The Journal of Urology
Stone YangChun-Jen Huang

Abstract

The lipid lowering agent simvastatin has potent anti-oxidation capacity. We elucidated the potential of simvastatin to attenuate testicular injury induced by testicular torsion-detorsion. We also investigated simvastatin effects on nuclear factor-kappaB expression. We allocated 60 adult male Sprague-Dawley(R) rats to testicular torsion-detorsion, torsion-detorsion plus simvastatin (1 or 5 mg/kg), sham operation or sham operation plus simvastatin (5 mg/kg). There were 12 rats per group. Simvastatin was administered immediately after detorsion or immediately after sham operation. Testes were harvested 30 minutes and 24 hours after detorsion to facilitate the evaluation of nuclear factor-kappaB and testicular injury, respectively. Histological findings revealed severe injury in testes of the torsion-detorsion and torsion-detorsion-simvastatin (1 mg/kg) groups while testes in the torsion-detorsion-simvastatin (5 mg/kg) group showed moderate injury. Myeloperoxidase activity, and cytokines, nitric oxide and malondialdehyde in testes in the torsion-detorsion-simvastatin (5 mg/kg) group were significantly lower than in the torsion-detorsion group. Values were comparable in the torsion-detorsion-simvastatin (1 mg/kg) and torsion-detorsi...Continue Reading

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Citations

Apr 30, 2013·Biological Trace Element Research·Amr A FouadIyad Jresat
Jul 19, 2011·Journal of Pediatric Surgery·Si-Ming WeiJian Zhou
Apr 12, 2015·The Journal of Surgical Research·Hung-Jen ShihChun-Jen Huang
Dec 24, 2014·The Journal of Surgical Research·Chen-Hsien YangChun-Jen Huang
May 25, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Shogo ShimizuMotoaki Saito
Dec 12, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Bahram Eslami FarsaniEsrafil Mansouri

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