Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells

Oncology Reports
Cristian G TorresCaroll Stoore

Abstract

Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The existence of a subpopulation of cancer cells with stemness features called cancer stem-like cells, may explain in part these characteristics of tumor progression. The statins, potent blockers of cholesterol synthesis, have also shown antitumor effects on cancer mammary cells, changes mediated by a decrease in the isoprenylation of specific proteins. Few studies have shown that simvastatin, a lipophilic statin, sensitizes cancer stem-like cells eliminating drug resistance. The aim of the present study was to evaluate the effects of simvastatin on spheres derived from CF41.Mg canine mammary tumor cells, which were characterized by phenotypic and functional analyses. Spheres exhibited characteristics of stemness, primarily expressing a CD44⁺/CD24⁻/low phenotype, displaying auto-renewal and relative chemoresistance. Exposure to simvastatin induced a decrease in the sphere-forming capacity and cell viability, accompanied by a concentration- and time-dependent increase in caspase-3/7 activity. In addition, modulatio...Continue Reading

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Citations

Aug 12, 2020·Veterinary and Comparative Oncology·Kosuke KobayashiMasaru Okuda
Dec 21, 2016·Acta Veterinaria Scandinavica·Agata Rybicka, Magdalena Król
Nov 7, 2019·BMC Veterinary Research·Consuelo SerranoCristian Gabriel Torres
Dec 29, 2020·Journal of Veterinary Pharmacology and Therapeutics·Min-Soo Kim, In-Hwan Baek
Mar 9, 2021·Frontiers in Veterinary Science·Guillermo ValdiviaLaura Peña
Oct 18, 2021·Veterinary and Comparative Oncology·Takuro IshikawaKatsuhiko Warita

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