Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism

Scientific Reports
Vasundhara KainUday Saxena

Abstract

Statins are a class of oral drugs that are widely used for treatment of hypercholesterolemia. Recent clinical data suggest that chronic use of these drugs increases the frequency of new onset diabetes. Studies to define the risks of statin-induced diabetes and its underlying mechanisms are clearly necessary. We explored the possible mechanism of statin induced insulin resistance using a well-established cell based model and simvastatin as a prototype statin. Our data show that simvastatin induces insulin resistance in a cholesterol biosynthesis inhibition independent fashion but does so by a fatty acid mediated effect on insulin signaling pathway. These data may help design strategies for prevention of statin induced insulin resistance and diabetes in patients with hypercholesterolemia.

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Citations

Mar 3, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alexei A PodtelezhnikovKeith Q Tanis
Aug 29, 2019·Journal of Translational Medicine·Estela Lorza-GilHelena C F Oliveira
Jul 8, 2020·International Journal of Molecular Sciences·Unai Galicia-GarciaCésar Martín
Feb 22, 2017·Frontiers in Pharmacology·Feng XueYan-Dong Wang
Dec 7, 2016·Critical Care : the Official Journal of the Critical Care Forum·Alessandro PutzuGiovanni Landoni
Feb 6, 2017·Current Diabetes Reports·Markku Laakso, Johanna Kuusisto
Aug 27, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Fahim AbbasiJoshua W Knowles

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Methods Mentioned

BETA
GTPase
fatty acid assay

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