SIN-1, a nitric oxide donor, ameliorates experimental allergic encephalomyelitis in Lewis rats in the incipient phase: the importance of the time window

The Journal of Immunology : Official Journal of the American Association of Immunologists
L Y XuB G Xiao

Abstract

NO is involved in the regulation of immune responses. The role of NO in the pathogenesis of experimental allergic encephalomyelitis (EAE) is controversial. In this study, 3-morpholinosydnonimine (SIN-1), an NO donor, was administered to Lewis rats on days 5-7 postimmunization, i.e., during the incipient phase of EAE. SIN-1 reduced clinical signs of EAE compared with those in PBS-treated control rats and was accompanied by reduced ED1(+) macrophages and CD4(+) T cell infiltration within the CNS. Blood mononuclear cells (MNC) obtained on day 14 postimmunization revealed that SIN-1 administration enhanced NO and IFN-gamma production by blood MNC and suppressed Ag- and mitogen-induced proliferative responses. MHC class II, B7-1 and B7-2 were down-regulated in SIN-1-treated EAE rats. Simultaneously, frequencies of apoptotic cells among blood MNC were increased. In vivo, SIN-1 is likely to behave as an NO donor. Administration of SIN-1 induced NO production, but did not affect superoxide and peroxynitrite formation. Enhanced NO production during the priming phase of EAE thus promotes apoptosis, down-regulates disease-promoting immune reactivities, and ameliorates clinical EAE, mainly through SIN-1-derived NO, without depending on NO ...Continue Reading

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Citations

Mar 12, 2013·Antioxidants & Redox Signaling·Djordje Miljković, Ivan Spasojević
Apr 5, 2003·Immunopharmacology and Immunotoxicology·H J KwakH T Chung
Aug 28, 2003·Immunology·Lingyun XuYouhai H Chen
Aug 25, 2005·European Journal of Clinical Nutrition·M E van MeeterenE A F van Tol
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing ZhuSamia J Khoury
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Nov 23, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Patrick J McNamaraRobert P Jankov
May 4, 2005·Current Neurology and Neuroscience Reports·Juan Manuel EncinasGrigori Enikolopov
Jul 26, 2011·Journal of Neuroinflammation·Jeroen F J BogieJerome J A Hendriks

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