PMID: 22328955Feb 14, 2012Paper

Sinecatechins: Effects on HPV-Induced Enzymes Involved in Inflammatory Mediator Generation.

The Journal of Clinical and Aesthetic Dermatology
Stephen K Tyring

Abstract

Based on published studies, the biological properties of green tea catechins are antiviral, antioxidative, anticarcinogenic, antiangiogenic, and immunostimulatory. The United States Food and Drug Administration has approved a topical ointment formulation of sinecatechins, derived from green tea catechins and other tea components, for the treatment of external genital and perianal warts. The exact mechanism of action of sinecatechins in eradication of human papillomavirus-induced external genital and perianal warts is unknown, but may be due to one or more of the mechanisms mentioned. This study was conducted to investigate the effects of sinecatechins on proteases, inflammatory enzymes, and kinases contributing to human papillomavirus expression and growth. Using commercially available in-vitro biochemical assays, sinecatechins were tested for their activity against matrix metalloproteinase (MMP-1, MMP-2, MMP-7, MMP-9); enzymes involved in oxidative stress (lipoxygenases and cyclooxygenases [COX-1, COX-2]); several growth factors (epidermal growth factor, platelet-derived growth factor, and transforming growth factor-β); and extracellular signal-regulated kinases 1/2. The ability of sinecatechins to inhibit ligand binding of gr...Continue Reading

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