Sinecatechins ointment for the treatment of warts in children

Pediatric Dermatology
Maya DeebIrene Lara-Corrales

Abstract

Sinecatechins ointment, a green tea derivative, is a novel agent approved for the treatment of anogenital warts in immunocompetent adults and has been reported to be effective in treating extragenital warts as well. Data are lacking in children. We sought to determine the efficacy and tolerability of sinecatechins ointment for treating warts in children. A retrospective cohort study was conducted of children with anogenital and/or extragenital warts treated with sinecatechins ointment for at least 1 month. The primary outcome was frequency of complete response (total resolution of warts at follow-up). Secondary outcomes included frequency of partial response (reduction in number and/or size of warts) and adverse events. There was no control group for comparison. Of 24 patients who met the inclusion criteria, 14 (58.3%) had anogenital warts, 7 (29.2%) had extragenital warts, and 3 (12.5%) had both anogenital and extragenital warts. Mean age at treatment initiation was 8.0 years (SD = 3.9). Median duration of warts at treatment initiation was 1.2 years (range 0.09-12.62). Sixteen patients (66.7%) experienced a reduction in the number and/or size of the warts. Four patients (16.7%) had complete resolution. Median treatment duratio...Continue Reading

References

Jun 18, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Stina Syrjänen
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Chun Shing KwokRachel Abbott
Sep 11, 2013·Annals of Family Medicine·Sjoerd C BrugginkJacobijn Gussekloo
Dec 18, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·A Clouth, H Schöfer
Sep 30, 2014·Actas dermo-sifiliográficas·J Alcántara GonzálezL Calzado Villarreal
Apr 17, 2015·Pediatric Dermatology·Anne M KuwabaraBernard A Cohen
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Nov 11, 2016·The Pediatric Infectious Disease Journal·Filip RobJana Hercogová

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Citations

Jun 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Noriyuki MiyoshiYukihiko Hara
Jun 15, 2019·Pediatric Dermatology·Bahir H ChamseddinAdnan Mir

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