Single-acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
M C FischerR Rizi

Abstract

Magnetic resonance imaging (MRI) with hyperpolarized 3-helium gas (HP 3He) offers the possibility of studying functional lung parameters such as the alveolar oxygen concentration and oxygen depletion rate. Until now, a double-acquisition technique has been utilized to extract these parameters. A complicated single-acquisition technique was previously developed to avoid the necessity of performing two identical breathing maneuvers. The results obtained with this technique were significantly less accurate than the results obtained with the double-acquisition method. In this work, a novel, easily implemented single-acquisition sequence is presented that provides results comparable to those obtained with the established double-acquisition method. This method is demonstrated in a phantom and a pig model on a 1.5 T scanner using a 2D fast low-angle shot (FLASH) gradient-echo sequence. Numerical simulations of the time evolution of the oxygen concentration were performed. Simulation results are presented to support the experimental data. Various parameter regimes were experimentally and numerically investigated.

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Citations

Apr 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rahim R Rizi
Aug 19, 2009·Proceedings of the American Thoracic Society·Kiarash EmamiRahim R Rizi
Sep 30, 2006·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Hirohiko ImaiHideaki Fujiwara
Aug 21, 2015·Expert Review of Clinical Immunology·Ruth HartleySumit Gupta
Jul 29, 2015·Journal of Magnetic Resonance Imaging : JMRI·Stanley J KrugerSean B Fain
May 20, 2008·Academic Radiology·Richard A GuyerRahim R Rizi
May 14, 2008·Magnetic Resonance Imaging Clinics of North America·Shin MatsuokaHiroto Hatabu
Oct 13, 2007·European Journal of Radiology·Nicolau BeckmannAlexandre Trifilieff
Feb 21, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiangsheng YuRahim R Rizi
Feb 1, 2012·NMR in Biomedicine·Kiarash EmamiRahim R Rizi
Dec 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hooman HamedaniRahim R Rizi
Jan 29, 2013·Journal of Magnetic Resonance Imaging : JMRI·John P Mugler, Talissa A Altes
Feb 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hooman HamedaniRahim R Rizi
Nov 18, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G Wilson MillerJames R Brookeman
Nov 9, 2004·Academic Radiology·Z Z SpectorR R Rizi
Oct 29, 2005·Academic Radiology·Solbert Permutt
Oct 29, 2005·Academic Radiology·Martin C FischerRahim R Rizi
Jun 22, 2005·Respiratory Physiology & Neurobiology·Wolfgang G SchreiberHans-Ulrich Kauczor
Feb 8, 2005·Radiologic Clinics of North America·Masaru IshiiRahim R Rizi
Jun 17, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ronn P WalvickMitchell S Albert
Oct 23, 2013·Magnetic Resonance Imaging·Joseph S SixThomas Meersmann
Dec 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Katarzyna CieślarYannick Crémillieux
Apr 26, 2007·Journal of Magnetic Resonance Imaging : JMRI·Jiangsheng YuRahim R Rizi
Apr 25, 2007·NMR in Biomedicine·Katarzyna CieślarYannick Crémillieux
Dec 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiangsheng YuRahim R Rizi
Apr 6, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ray F LeeGeorgeann McGuinness
Apr 6, 2007·Journal of Magnetic Resonance Imaging : JMRI·Sean B FainThomas M Grist
Nov 2, 2014·Reports on Progress in Physics·Kai Ruppert
Dec 13, 2006·Journal of Applied Physiology·Susan R HopkinsRahim R Rizi
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Z Z SpectorR R Rizi
Oct 16, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Justin ClappRahim R Rizi
Apr 7, 2017·Physics in Medicine and Biology·Erin B AdamsonSean B Fain
Oct 26, 2018·Physiological Reviews·Thomas P Keeley, Giovanni E Mann
Feb 3, 2021·The British Journal of Radiology·Yoshiharu OhnoHiroshi Toyama

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